Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
J Perinatol. 2022 Oct;42(10):1338-1345. doi: 10.1038/s41372-022-01446-x. Epub 2022 Jul 1.
Describe 1-month outcomes among newborns of persons with perinatal COVID-19.
Prospective observational study of pregnant persons who tested positive for SARS-CoV-2 between 14 days before and 3 days after delivery and their newborns, from 3/2020 to 3/2021 at two urban high-risk academic hospitals. Phone interviews were conducted to determine 1-month newborn outcomes.
Among 9748 pregnant persons, 209 (2.1%) tested positive for perinatal SARS-CoV-2. Symptomatically infected persons were more likely to have a preterm delivery due to worsening maternal condition and their newborns were more likely to test positive for SARS-CoV-2 compared with asymptomatic persons. Six of 191 (3.1%) infants tested were positive for SARS-CoV-2; none had attributable illness before discharge. Of 169 eligible families, 132 (78.1%) participated in post-discharge interviews; none reported their newborn tested positive for SARS-CoV-2 by 1 month of age.
Symptomatic perinatal COVID-19 had a substantial effect on maternal health but no apparent short-term effect on newborns.
描述围产期 COVID-19 患者新生儿的 1 个月结局。
这是一项前瞻性观察性研究，纳入了 2020 年 3 月至 2021 年 3 月期间在两家城市高风险学术医院分娩的、产前 14 天至产后 3 天期间 SARS-CoV-2 检测呈阳性的孕妇及其新生儿。通过电话访谈来确定新生儿 1 个月时的结局。
在 9748 名孕妇中，有 209 名（2.1%）围产期 SARS-CoV-2 检测呈阳性。与无症状感染者相比，有症状感染者更有可能因母体病情恶化而早产，且其新生儿更有可能 SARS-CoV-2 检测呈阳性。191 例新生儿中有 6 例（3.1%）检测出 SARS-CoV-2 呈阳性；在出院前均无相关疾病。在 169 个符合条件的家庭中，有 132 个（78.1%）参与了出院后访谈；在 1 个月大时，没有家庭报告其新生儿 SARS-CoV-2 检测呈阳性。
有症状的围产期 COVID-19 对产妇健康有很大影响，但对新生儿似乎没有明显的短期影响。
