围产期 COVID-19 产妇和新生儿结局在两家学术型妇产医院。
Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals.
机构信息
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
出版信息
J Perinatol. 2022 Oct;42(10):1338-1345. doi: 10.1038/s41372-022-01446-x. Epub 2022 Jul 1.
OBJECTIVE
Describe 1-month outcomes among newborns of persons with perinatal COVID-19.
STUDY DESIGN
Prospective observational study of pregnant persons who tested positive for SARS-CoV-2 between 14 days before and 3 days after delivery and their newborns, from 3/2020 to 3/2021 at two urban high-risk academic hospitals. Phone interviews were conducted to determine 1-month newborn outcomes.
RESULTS
Among 9748 pregnant persons, 209 (2.1%) tested positive for perinatal SARS-CoV-2. Symptomatically infected persons were more likely to have a preterm delivery due to worsening maternal condition and their newborns were more likely to test positive for SARS-CoV-2 compared with asymptomatic persons. Six of 191 (3.1%) infants tested were positive for SARS-CoV-2; none had attributable illness before discharge. Of 169 eligible families, 132 (78.1%) participated in post-discharge interviews; none reported their newborn tested positive for SARS-CoV-2 by 1 month of age.
CONCLUSION
Symptomatic perinatal COVID-19 had a substantial effect on maternal health but no apparent short-term effect on newborns.
目的
描述围产期 COVID-19 患者新生儿的 1 个月结局。
研究设计
这是一项前瞻性观察性研究，纳入了 2020 年 3 月至 2021 年 3 月期间在两家城市高风险学术医院分娩的、产前 14 天至产后 3 天期间 SARS-CoV-2 检测呈阳性的孕妇及其新生儿。通过电话访谈来确定新生儿 1 个月时的结局。
结果
在 9748 名孕妇中，有 209 名（2.1%）围产期 SARS-CoV-2 检测呈阳性。与无症状感染者相比，有症状感染者更有可能因母体病情恶化而早产，且其新生儿更有可能 SARS-CoV-2 检测呈阳性。191 例新生儿中有 6 例（3.1%）检测出 SARS-CoV-2 呈阳性；在出院前均无相关疾病。在 169 个符合条件的家庭中，有 132 个（78.1%）参与了出院后访谈；在 1 个月大时，没有家庭报告其新生儿 SARS-CoV-2 检测呈阳性。
结论
有症状的围产期 COVID-19 对产妇健康有很大影响，但对新生儿似乎没有明显的短期影响。
Zotero 插件