Surgical Outcomes and Applied Research Program, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.
Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado Denver, Anschutz Medical Campus, 12631 E. 17th Avenue, C-310, Room 6602, Aurora, CO, 80045, USA.
World J Surg. 2022 Oct;46(10):2365-2376. doi: 10.1007/s00268-022-06638-2. Epub 2022 Jul 1.
Comorbidities and postoperative complications increase mortality, making early recognition and management critical. It is useful to understand how they are associated with one another. This study assesses associations between comorbidities, complications, and mortality.
We calculated associations between comorbidities, complications, and 30-day mortality using the 2012-2018 ACS-NSQIP database. We examined the association between mortality and number of complications which complications were most associated with mortality.
5,777,108 patients were included. 30-day mortality was 0.95%. For most comorbidities or postoperative complications, patients with these had higher mortality than patients without. Having ≥ 1 complication increased mortality risk by 32.5-fold (6.5% vs. 0.2%). Mortality rate significantly increased with increasing number of complications, particularly after two or more complications. Bleeding and sepsis were associated with the most deaths.
The 30-day mortality rate was < 1% but was 32-fold higher in patients with complications and increased rapidly for patients with ≥ 2 complications. Bleeding and sepsis were the most prominent complications associated with mortality.
合并症和术后并发症会增加死亡率，因此早期识别和管理至关重要。了解它们之间的关联很有用。本研究评估了合并症、并发症和死亡率之间的关系。
我们使用 2012-2018 年 ACS-NSQIP 数据库计算了合并症、并发症和 30 天死亡率之间的关联。我们研究了死亡率与并发症数量之间的关系，以及哪些并发症与死亡率最相关。
共纳入 5777108 例患者。30 天死亡率为 0.95%。对于大多数合并症或术后并发症，患有这些疾病的患者的死亡率高于没有这些疾病的患者。患有≥1 种并发症的患者的死亡率增加了 32.5 倍（6.5%比 0.2%）。死亡率随着并发症数量的增加而显著增加，尤其是在有两种或更多种并发症后。出血和败血症与死亡人数最多有关。
30 天死亡率<1%，但患有并发症的患者的死亡率高出 32 倍，且患有≥2 种并发症的患者死亡率迅速上升。出血和败血症是与死亡率最相关的最突出的并发症。
