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癌症治疗引起的乳腺癌和前列腺癌患者的骨质流失。

Bone loss induced by cancer treatments in breast and prostate cancer patients.

机构信息

Department of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Catedra UAM-Roche, EPID-Future, Universidad Autónoma de Madrid, Madrid, Spain.

Department of Medical Oncology, Hospital Virgen del Rocío, Seville, Spain.

出版信息

Clin Transl Oncol. 2022 Nov;24(11):2090-2106. doi: 10.1007/s12094-022-02872-1. Epub 2022 Jul 2.

Abstract

Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone fragility and risk of fracture. Cancer-associated bone loss is a multifactorial process, and optimal interdisciplinary management of skeletal health, accurate assessment of bone density, and early diagnosis are essential when making decisions aimed at reducing bone loss and fracture risk in patients who have received or are receiving treatment for cancer. In this document, a multidisciplinary group of experts collected the latest evidence on the pathophysiology of osteoporosis and its prevention, diagnosis, and treatment with the support of the Spanish scientific society SEOM. The aim was to provide an up-to-date and in-depth view of osteoporotic risk and its consequences, and to present a series of recommendations aimed at optimizing the management of bone health in the context of cancer.

摘要

癌症和癌症治疗是导致骨质疏松症的一个主要危险因素,因为它会导致骨质流失和骨微结构恶化。这两个因素都会导致骨强度降低,从而使骨骼变得更加脆弱,骨折风险增加。癌症相关的骨质流失是一个多因素的过程,因此,在做出旨在降低接受或正在接受癌症治疗的患者骨质流失和骨折风险的决策时,对骨骼健康进行最佳的跨学科管理、准确评估骨密度和早期诊断至关重要。在本文件中,一个多学科专家组在西班牙科学协会 SEOM 的支持下,收集了有关骨质疏松症的病理生理学及其预防、诊断和治疗的最新证据。其目的是提供一个关于骨质疏松风险及其后果的最新和深入的观点,并提出一系列建议,旨在优化癌症背景下的骨骼健康管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f6/9522722/fdb9f4b6dd87/12094_2022_2872_Fig1_HTML.jpg

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