Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas (UFAL), Alagoas, Brazil.
Laboratório de Morfogênese Celular (LMC), Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Laboratório de Biomedicina do Cérebro, Instituto Estadual do Cérebro Paulo Niemeyer (IECPN), Secretaria de Estado de Saúde, Rio de Janeiro, Brazil; Programa de Pós-Graduação em Neurociência Translacional, Instituto Nacional de Neurociência Translacional (INNT-UFRJ), Brazil.
Eur J Cell Biol. 2022 Jun-Aug;101(3):151252. doi: 10.1016/j.ejcb.2022.151252. Epub 2022 Jun 26.
The inner ear is composed by tiny and complex structures that, together with peripheral and central auditory pathways, are responsible for hearing processing. However, not only the anatomy of the cochlea, its compartments and related structures are complex. The mechanisms involved in the regulation of homeostasis in the inner ear fluid, which determines the ionic gradient necessary for hearing and balancing sensory excitability, is an intricate phenomenon that involves several molecules. Among them, Aquaporins (AQP) play a significant role in this process. AQP are part of a family of small, integral membrane proteins that regulate different processes, including bidirectional water and ionic flow in the inner ear. Changes in the expression of these proteins are essential to auditory physiology and several pathophysiological processes in the inner ear. This review focuses on the role of AQP in health and disease of the auditory system.
内耳由微小而复杂的结构组成，这些结构与外周和中枢听觉通路一起负责听觉处理。然而，不仅耳蜗的解剖结构、其腔室和相关结构很复杂。参与内耳液体内稳态调节的机制也是一个复杂的现象，涉及到几种分子。其中，水通道蛋白（AQP）在这个过程中起着重要的作用。AQP 是一组小的、完整的膜蛋白家族，调节包括内耳中双向水和离子流在内的多种不同过程。这些蛋白质表达的变化对内耳听觉生理学和几种病理生理过程至关重要。本综述重点介绍了 AQP 在听觉系统健康和疾病中的作用。
