水通道蛋白介导的内耳液体调节
Aquaporin-mediated fluid regulation in the inner ear.
作者信息
Beitz Eric, Zenner Hans-Peter, Schultz Joachim E
机构信息
Department of Pharmaceutical Biochemistry, School of Pharmacy, University of Tübingen, 72076 Tübingen, Germany.
出版信息
Cell Mol Neurobiol. 2003 Jun;23(3):315-29. doi: 10.1023/a:1023636620721.
Abstract
- The sensory functions of the inner ear (hearing and balance) critically depend on the precise regulation of two fluid compartments of highly desparate ion composition, i.e., the endolymph and the perilymph. 2. The parameters volume, ion composition, and pH need to be held at homeostasis irrespective of the hydration status of the total organism. 3. Specific cellular water channels, aquaporins, have been shown to be essential for the fluid regulation of several organs, e.g., kidney, lung, and brain. 4. Because of functional similarities of water regulation in the kidney and inner ear this review initially summarizes some aquaporin functions in the kidney and then focuses on 6 out of 11 mammalian aquaporins that are present in the inner ear (AQP1-6). 5. Their potential role in the inner ear fluid control will be discussed on the basis of the respective expression patterns and individual pore properties. 6. Further, a working model is presented of how the endolymphatic sac may contribute to inner ear fluid regulation.
摘要
- 内耳的感觉功能（听觉和平衡）严重依赖于两种离子组成差异极大的液体腔室的精确调节，即内淋巴和外淋巴。2. 无论机体的水合状态如何，体积、离子组成和pH值等参数都需要保持在稳态。3. 特定的细胞水通道，即水通道蛋白，已被证明对肾脏、肺和大脑等多个器官的液体调节至关重要。4. 由于肾脏和内耳在水调节方面的功能相似性，本综述首先总结了水通道蛋白在肾脏中的一些功能，然后重点关注内耳中存在的11种哺乳动物水通道蛋白中的6种（AQP1 - 6）。5. 将根据它们各自的表达模式和单个孔道特性来讨论它们在内耳液体控制中的潜在作用。6. 此外，还提出了一个关于内淋巴囊如何有助于内耳液体调节的工作模型。
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本文引用的文献
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