Dr Iffath Meherubin, Assistant Professor, Department of Physiology, Sheikh Hasina Medical College, Jamalpur, Bangladesh; E-mail:
Mymensingh Med J. 2022 Jul;31(3):600-605.
The serum Alanine Transaminase (ALT) activity has been regarded as a reliable and sensitive marker of liver disease. In the context of obesity ALT may also be a good indicator of overall health. Obesity has been reported as a risk factor associated with elevation of ALT, which is a surrogate marker of Non-alcoholic fatty liver disease (NAFLD). Elevated ALT may correlate with the severity of NAFLD in obese female. This study was done to evaluate the changes of serum ALT in obese female age ranged 30-60 years in comparison to normal healthy female of same age. At the same time we can know the relationship between body mass index and serum ALT concentration in obese female. This analytical cross-sectional study was carried out in the Department of Physiology, Mymensingh Medical College, Mymensingh, Bangladesh from January 2020 to December 2020. A total number of 100 female subjects were included in this study. Among them fifty (50) normal healthy female were taken as control group (Group I) and fifty (50) obese female were taken as study group (Group II). The level of serum ALT was determined by Ultra violet (UV) method. Data were expressed as mean±SD and statistical significance of difference among the group was calculated by unpaired Student's 't' test. Pearson's correlation coefficient test was done to find the correlation of serum ALT with BMI by using SPSS (version 21.0). During interpretation of results, p values of <0.001 were considered as statistically highly significant. In this study, serum level of ALT was significantly higher (p<0.001) in obese female compared to those of healthy control female. In addition, there is a positive correlation of serum ALT with BMI. From the results of the present study, it can be concluded that, elevated ALT was significantly associated with high BMI as well as with other feature of NAFLD.
血清丙氨酸氨基转移酶（ALT）活性一直被认为是肝脏疾病的可靠和敏感标志物。在肥胖的背景下，ALT 也可能是整体健康的良好指标。肥胖已被报道为与 ALT 升高相关的危险因素，ALT 是非酒精性脂肪性肝病（NAFLD）的替代标志物。在肥胖女性中，升高的 ALT 可能与 NAFLD 的严重程度相关。本研究旨在评估 30-60 岁肥胖女性与同年龄正常健康女性的血清 ALT 变化。同时，我们可以了解肥胖女性的体重指数（BMI）与血清 ALT 浓度之间的关系。本分析性横断面研究于 2020 年 1 月至 2020 年 12 月在孟加拉国迈门辛医科大学生理学系进行。本研究共纳入 100 名女性受试者。其中，50 名正常健康女性作为对照组（I 组），50 名肥胖女性作为研究组（II 组）。采用紫外（UV）法测定血清 ALT 水平。数据表示为均值±标准差，采用未配对学生 't' 检验计算组间差异的统计学意义。采用 SPSS（版本 21.0）进行 Pearson 相关系数检验，以寻找血清 ALT 与 BMI 的相关性。在解释结果时，p 值<0.001 被认为具有统计学高度显著性。本研究中，肥胖女性的血清 ALT 水平明显高于健康对照组（p<0.001）。此外，血清 ALT 与 BMI 呈正相关。根据本研究的结果，可以得出结论，升高的 ALT 与高 BMI 以及 NAFLD 的其他特征明显相关。
