Patias Naiéle Sartori, de Queiroz Eveline Aparecida Isquierdo Fonseca, Ferrarini Stela Regina, Bomfim Gisele Facholi, Aguiar Danilo Henrique, Sinhorin Adilson Paulo, Bello Alexandre Aymberé, da Silva Geovana Vicentini Fazolo, Cavalheiro Larissa, Sinhorin Valéria Dornelles Gindri
Postgraduate Program in Biotechnology and Biodiversity of the Pro Centro-Oeste Network, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.
NUPADS-Health Research and Teaching Support Center, Institute of Health Science, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil.
Biology (Basel). 2024 Jul 17;13(7):535. doi: 10.3390/biology13070535.
Obesity, a chronic disease, resulted from excessive consumption of high-calorie foods, leading to an energy imbalance. () was used in folk medicine for its analgesic, anti-inflammatory, and healing properties. The association of the extract from with nanotechnology was innovative for combining high technology with active ingredients that are easily accessible in the Amazon region. This study evaluated the effect of liposomes containing the ethyl acetate fraction of the crude extract of leaves on obesity. Male Wistar rats treated with a high-calorie diet for 8 weeks to induce obesity received treatment with the liposome formulation containing extract (1 mg/kg/day, via gavage) for 14 days. Morphological, metabolic, redox status, immunological, and histological parameters were evaluated in the adipose and liver tissue of the animals. The groups were divided as follows: C: control; P: liposomes containing extract; O: obese, and OP: obese + liposomes containing extract. The obesity model resulted in increases in body weight, caloric intake, body fat weight, and in the lipid profile. In adipose tissue, P decreased SOD (superoxide dismutase) activity in obese animals. In the liver, a positive modulation of the extract was observed in relation to glucose, amino acids, lactate, hepatoprotective action, and anti-inflammatory activity, with a decrease in interleukin 1β (IL-1β) in obese animals. The results showed an improvement in the functional and inflammatory aspects, but the treatment was not effective in alleviating general changes related to obesity, such as weight gain, fat, glucose, triglycerides, and inflammation in adipose tissue, highlighting the complexity of responses in different organs during obesity and treatment with .
肥胖是一种慢性疾病，由高热量食物的过度摄入导致能量失衡引起。（）因其止痛、抗炎和愈合特性而被用于民间医学。（）提取物与纳米技术的结合是一项创新，将高科技与亚马逊地区易于获取的活性成分相结合。本研究评估了含有（）叶粗提物乙酸乙酯部分的脂质体对肥胖的影响。用高热量饮食喂养8周以诱导肥胖的雄性Wistar大鼠接受含（）提取物的脂质体制剂治疗（1毫克/千克/天，经口灌胃）14天。对动物的脂肪和肝脏组织的形态学、代谢、氧化还原状态、免疫学和组织学参数进行了评估。分组如下：C：对照组；P：含提取物的脂质体组；O：肥胖组，OP：肥胖 + 含提取物的脂质体组。肥胖模型导致体重、热量摄入、体脂重量和血脂水平增加。在脂肪组织中，P降低了肥胖动物的超氧化物歧化酶（SOD）活性。在肝脏中，观察到提取物对葡萄糖、氨基酸、乳酸、肝脏保护作用和抗炎活性有正向调节作用，肥胖动物的白细胞介素1β（IL - 1β）减少。结果显示在功能和炎症方面有所改善，但该治疗在减轻与肥胖相关的一般变化方面无效，如体重增加、脂肪、葡萄糖、甘油三酯以及脂肪组织中的炎症，突出了肥胖及用（）治疗期间不同器官反应的复杂性。
