Multifunctional hemoporfin-CuS-MnO for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies.

Integrated theranostic nanoplatforms with multi-model imaging and therapeutic functions are attracting great attention in cancer treatments, while the design and preparation of such nanoplatforms remain an open challenge. Herein, we report hemoporfin@CuS@MnO nanoparticles (H@CuS@MnO NPs) as multifunctional nanoplatforms for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies of tumors. CuS hollow spherical nanoparticles were firstly prepared by in-situ vulcanization of CuO, and the growth of MnO shell was realized by the reduction of manganese permanganate, where the hollow structure of CuS could be used to load hemoporfin sonosensitizer. CuS@MnO nanoparticles with diameters of ∼ 130 nm exhibit increased photoabsorption in near-infrared (NIR) region (680-1100 nm) due to the plasmonic effect of CuS, and the photothermal conversion efficiency is determined to be 32.5% under 1064 nm laser irradiation. Furthermore, MnO shells can mimic catalase to trigger the decomposition of endogenous HO into O with a significant O elevation (14.7 mg L) within 8 min and then promote the production of O via sonodynamic effect of hemoporfin. Meanwhile, MnO shells provide the T-weight magnetic resonance (MR) imaging function. When H@CuS@MnO NPs solution is administered to the mice, the tumor growth can be effectively inhibited due to catalytically-assisted synergetic photothermal-sonodynamic therapies which have superior therapeutic effect compared to mono-model therapy alone. Thus, H@CuS@MnO NPs present a promising strategy for the development of integrated theranostic nanoplatforms with multi-model imaging and therapy functions.