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鞣酸介导合成花状介孔 MnO 纳米结构作为 T1-T2 双模态 MRI 造影剂和双酶模拟物。

Tannic acid-mediated synthesis of flower-like mesoporous MnO nanostructures as T-T dual-modal MRI contrast agents and dual-enzyme mimetic agents.

机构信息

Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Department of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

出版信息

Sci Rep. 2023 Sep 5;13(1):14606. doi: 10.1038/s41598-023-41598-0.

DOI:10.1038/s41598-023-41598-0
PMID:37670132
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10480446/
Abstract

This study introduces a simple method for preparing a new generation of MnO nanomaterials (MNMs) using tannic acid as a template. Two shapes of MnO NMs, flower-like M1-MnO and near-spherical M2-MnO, were prepared and compared as dual-active nanozymes and contrast agents in magnetic resonance imaging (MRI). Various parameters, including the crystallinity, morphology, magnetic saturation (M), surface functionality, surface area, and porosity of the MNMs were investigated. Flower-like M1-MnO NMs were biocompatible and exhibited pH-sensitive oxidase and peroxidase mimetic activity, more potent than near-spherical M2-MnO. Furthermore, the signal intensity and r relaxivity strongly depended on the crystallinity, morphology, pore size, and specific surface area of the synthesized MNMs. Our findings suggest that flower-like M1-MnO NM with acceptable dual-enzyme mimetic (oxidase-like and peroxidase-like) and T MRI contrast activities could be employed as a promising theranostic system for future purposes.

摘要

本研究介绍了一种使用单宁酸作为模板制备新一代 MnO 纳米材料（MNMs）的简单方法。制备了两种形状的 MnO NM，花状 M1-MnO 和近球形 M2-MnO，并将其用作磁共振成像（MRI）中的双活性纳米酶和对比剂。研究了 MNMs 的结晶度、形态、磁饱和（M）、表面功能、表面积和孔隙率等各种参数。花状 M1-MnO NM 具有生物相容性，并表现出 pH 敏感的氧化酶和过氧化物酶模拟活性，比近球形 M2-MnO 更有效。此外，信号强度和 r 弛豫率强烈依赖于所合成的 MNMs 的结晶度、形态、孔径和比表面积。我们的研究结果表明，具有可接受的双酶模拟（氧化酶样和过氧化物酶样）和 T MRI 对比活性的花状 M1-MnO NM 可用作未来治疗系统的有前途的治疗诊断系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/1e7f51fc5ad3/41598_2023_41598_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/ab9811775155/41598_2023_41598_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/b1d5017bda8b/41598_2023_41598_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/429277fc09b1/41598_2023_41598_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/e882b1e36c16/41598_2023_41598_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/214725902a02/41598_2023_41598_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/414c7c246a5d/41598_2023_41598_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/2d260841857c/41598_2023_41598_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/53c9c902d078/41598_2023_41598_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/42ed5524d123/41598_2023_41598_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/1e7f51fc5ad3/41598_2023_41598_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/ab9811775155/41598_2023_41598_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/b1d5017bda8b/41598_2023_41598_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/429277fc09b1/41598_2023_41598_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/e882b1e36c16/41598_2023_41598_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/214725902a02/41598_2023_41598_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/414c7c246a5d/41598_2023_41598_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/2d260841857c/41598_2023_41598_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/53c9c902d078/41598_2023_41598_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/42ed5524d123/41598_2023_41598_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee4/10480446/1e7f51fc5ad3/41598_2023_41598_Fig10_HTML.jpg

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引用本文的文献

[1]
Rapid synthesis of manganese dioxide nanoparticles for enhanced biocompatibility and theranostic applications.

RSC Adv. 2025-1-30

[2]
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本文引用的文献

[1]
Liquid exfoliation of ultrasmall zirconium carbide nanodots as a noninflammatory photothermal agent in the treatment of glioma.

Biomaterials. 2023-1

[2]
Cancer cell membrane-coated C-TiO hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy.

Acta Biomater. 2022-10-15

[3]
Multifunctional hemoporfin-CuS-MnO for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies.

J Colloid Interface Sci. 2022-11-15

[4]
Gadolinium-Based Contrast Agents: Updates and Answers to Typical Questions Regarding Gadolinium Use.

Tex Heart Inst J. 2022-5-1

[5]
Highly water-dispersible calcium lignosulfonate-capped MnO nanoparticles as a MRI contrast agent with exceptional colloidal stability, low toxicity and remarkable relaxivity.

RSC Adv. 2019-12-6

[6]
Fe-Coordinated Carbon Nanozyme Dots as Peroxidase-Like Nanozymes and Magnetic Resonance Imaging Contrast Agents.

ACS Appl Bio Mater. 2021-7-19

[7]
Effects of Calcination Temperature on the Phase Composition, Photocatalytic Degradation, and Virucidal Activities of TiO Nanoparticles.

ACS Omega. 2021-3-25

[8]
Multi-stimuli responsive hollow MnO-based drug delivery system for magnetic resonance imaging and combined chemo-chemodynamic cancer therapy.

Acta Biomater. 2021-5

[9]
Extract-Mediated ZnO Nanoparticles Loaded with Indole-3-Carbinol for Enhancement of Anticancer Efficacy in the A549 Human Lung Carcinoma Cell Line.

Materials (Basel). 2020-7-17

[10]
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