Huebers H A, Huebers E, Csiba E, Rummel W, Finch C A
Am J Clin Nutr. 1987 May;45(5):1007-12. doi: 10.1093/ajcn/45.5.1007.
Test solutions of cadmium and labeled iron salts, soluble complexes of diferric transferrin, or hemoglobin iron were introduced orally or were injected into tied-off jejunal segments in rat. Cadmium reduced the absorption of iron salts to about half in both normal and iron-deficient rats. Hemoglobin iron absorption was enhanced, indicating that the processing of this form or iron and its release from mucosa to blood was intact. A greater reduction in iron absorption occurred in iron-deficient rats when transferrin iron was injected into gut loops. Mucosal radioiron content in animals given cadmium with either iron salts or transferrin iron was increased. The primary effect of cadmium was on intracellular processing of iron salts and transferrin iron. The major portion of cadmium taken up by the mucosa of normal animals was bound to ferritin, and the effect of cadmium within the mucosal cell may be reduced thus.
将镉及标记铁盐的测试溶液、双铁转铁蛋白的可溶性复合物或血红蛋白铁经口给予大鼠，或注入大鼠结扎的空肠段。镉使正常大鼠和缺铁大鼠的铁盐吸收降低约一半。血红蛋白铁的吸收增强，表明这种形式的铁的加工及其从黏膜到血液的释放是完整的。当将转铁蛋白铁注入肠袢时，缺铁大鼠的铁吸收减少得更多。给予镉与铁盐或转铁蛋白铁的动物黏膜放射性铁含量增加。镉的主要作用是对铁盐和转铁蛋白铁的细胞内加工。正常动物黏膜摄取的镉大部分与铁蛋白结合，因此镉在黏膜细胞内的作用可能会降低。
