Shanghai Institute of Immunology, Department of Gastroenterology of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shanghai Institute of Immunology, Department of Gastroenterology of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Prog Lipid Res. 2022 Jul;87:101178. doi: 10.1016/j.plipres.2022.101178. Epub 2022 Jun 30.
Fatty acid binding proteins (FABPs) are key proteins in lipid transport, and the isoforms are segregated according to their tissue origins. Several isoforms, such as adipose-FABP and epidermal-FABP, have been shown to participate in multiple pathologic processes due to their ubiquitous expression. Intestinal fatty acid binding protein, also termed FABP2 or I-FABP, is specifically expressed in the small intestine. FABP2 can traffic lipids from the intestinal lumen to enterocytes and bind superfluous fatty acids to maintain a steady pool of fatty acids in the epithelium. As a lipid chaperone, FABP2 can also carry lipophilic drugs to facilitate targeted transport. When the integrity of the intestinal epithelium is disrupted, FABP2 is released into the circulation. Thus, it can potentially serve as a clinical biomarker. In this review, we discuss the pivotal role of FABP2 in intestinal lipid metabolism. We also summarize the molecular interactions that have been reported to date, highlighting the clinical prospects of FABP2 research.
脂肪酸结合蛋白（FABPs）是脂质转运的关键蛋白，其同工型根据组织来源进行分离。由于广泛表达，几种同工型，如脂肪 FABP 和表皮 FABP，已被证明参与多种病理过程。肠脂肪酸结合蛋白，也称为 FABP2 或 I-FABP，特异性表达于小肠。FABP2 可以将脂质从肠腔转运到肠上皮细胞，并结合多余的脂肪酸，以维持上皮细胞中脂肪酸的稳定池。作为一种脂质伴侣蛋白，FABP2 还可以携带亲脂性药物，以促进靶向运输。当肠上皮细胞的完整性被破坏时，FABP2 会被释放到循环中。因此，它可能作为一种临床生物标志物。在这篇综述中，我们讨论了 FABP2 在肠道脂质代谢中的关键作用。我们还总结了迄今为止报道的分子相互作用，突出了 FABP2 研究的临床前景。
