Hestiantoro Andon, Astuti Brilliant Putri Kusuma, Joyo Ericko Ongko, Febri Ririn Rahmala, Silvana Vita, Muharam Raden
Department of Obstetrics and Gynecology, Division of Reproductive Immunoendocrinology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
Human Reproductive, Infertility and Family Planning Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia
J Turk Ger Gynecol Assoc. 2022 Sep 5;23(3):130-136. doi: 10.4274/jtgga.galenos.2022.2022-2-1. Epub 2022 Jul 5.
Nutritional intake is one of the most common environmental risk factors for polycystic ovary syndrome (PCOS) because it is associated with obesity and insulin resistance. The aim of this study was to determine the relationship between micronutrient intake and androgen levels associated with PCOS.
This cross-sectional study was performed in patients with PCOS divided into two groups, normoandrogenic (NA) and hyperandrogenic (HA), and healthy controls. Dietary intake assessment was performed using a modified 38-item semi-quantitative food frequency questionnaire. Bivariate, correlation, and multivariate analyses were performed to determine the association between study variables.
There were 79 patients with PCOS, of whom 50 were NA and 29 were HA. There were 66 subjects in the healthy control group. The baseline characteristics in all groups were similar, except for body mass index and hormonal profile which were elevated in the HA group compared to the other groups. There was a significant negative correlation between the free androgen index (FAI) and intake of vitamin B, vitamin B, niacin, vitamin B, calcium, and iron in the NA group, while this association was absent in the HA group. Multivariate linear regression analysis showed that the intake of vitamin B, vitamin C, niacin, and iron had a significant effect on the FAI.
There is an effect of micronutrient intake on androgen levels in women with PCOS. The association was more significant in NA PCOS than in the HA PCOS groups. These findings suggest an association between micronutrients, androgens and PCOS at a systemic level.
营养摄入是多囊卵巢综合征（PCOS）最常见的环境风险因素之一，因为它与肥胖和胰岛素抵抗相关。本研究的目的是确定微量营养素摄入与PCOS相关雄激素水平之间的关系。
本横断面研究在PCOS患者中进行，这些患者分为两组，即正常雄激素组（NA）和高雄激素组（HA），并设置了健康对照组。使用经过修改的包含38个条目的半定量食物频率问卷进行饮食摄入评估。进行双变量分析、相关性分析和多变量分析以确定研究变量之间的关联。
共有79例PCOS患者，其中50例为NA组，29例为HA组。健康对照组有66名受试者。除体重指数和激素水平外，所有组的基线特征相似，与其他组相比，HA组的体重指数和激素水平升高。在NA组中，游离雄激素指数（FAI）与维生素B、维生素B、烟酸、维生素B、钙和铁的摄入量之间存在显著负相关，而在HA组中不存在这种关联。多变量线性回归分析表明，维生素B、维生素C、烟酸和铁的摄入量对FAI有显著影响。
微量营养素摄入对PCOS女性的雄激素水平有影响。这种关联在NA PCOS组中比在HA PCOS组中更显著。这些发现表明微量营养素、雄激素和PCOS在系统水平上存在关联。
