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先天性弓形虫病:我们还应该关注筛查吗?

Congenital toxoplasmosis: Should we still care about screening?

作者信息

Petersen Eskild, Meroni Valeria, Vasconcelos-Santos Daniel V, Mandelbrot Laurent, Peyron Francois

机构信息

Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark.

European Society for Clinical Microbiology and Infectious Diseases, Emerging Infections Task Force, Basel, Switzerland.

出版信息

Food Waterborne Parasitol. 2022 May 11;27:e00162. doi: 10.1016/j.fawpar.2022.e00162. eCollection 2022 Jun.

Abstract

Prenatal systematic screening for congenital toxoplasmosis has been performed in Austria and France since 1975 and neonatal screening for congenital toxoplasmosis has been part of the New England Newborn screening program since 1986. In this narrative review we review the data leading up to the systematic screening programs in Austria and France, highlighting the main finding of the European Union funded research in the 1990s and early 2000s. Different descriptive studies of the effect of pre- or postnatal treatment are discussed. has different genetic lineages with different pathogenicity in humans. This means that results in areas with a low pathogenic lineage cannot be extrapolated to an area with highly pathogenic lineages. The importance of meat as a source of infection is discussed in the light of an increased prevalence of in organic livestock production .

摘要

自1975年以来,奥地利和法国已开展先天性弓形虫病的产前系统筛查,自1986年起,先天性弓形虫病的新生儿筛查已成为新英格兰新生儿筛查项目的一部分。在这篇叙述性综述中,我们回顾了奥地利和法国开展系统筛查项目之前的数据,重点介绍了20世纪90年代和21世纪初由欧盟资助的研究的主要发现。讨论了产前或产后治疗效果的不同描述性研究。[病原体]在人类中有不同的遗传谱系,具有不同的致病性。这意味着在致病性较低的谱系地区所得到的结果不能外推到致病性较高的谱系地区。鉴于有机畜牧业生产中[病原体]的流行率上升,讨论了肉类作为感染源的重要性。

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