一种自动基因型消除算法。
An algorithm for automatic genotype elimination.
作者信息
Lange K, Goradia T M
出版信息
Am J Hum Genet. 1987 Mar;40(3):250-6.
Abstract
Automatic genotype elimination algorithms for a single locus play a central role in making likelihood computations on human pedigree data feasible. We present a simple algorithm that is fully efficient in pedigrees without loops. This algorithm can be easily coded and has been instrumental in greatly reducing computing times for pedigree analysis. A contrived counter-example demonstrates that some superfluous genotypes cannot be excluded for inbred pedigrees.
摘要
单基因座的自动基因型消除算法在使人类家系数据的似然计算变得可行方面发挥着核心作用。我们提出了一种简单的算法，该算法在无环家系中是完全有效的。此算法易于编码，并且在大幅减少家系分析的计算时间方面发挥了重要作用。一个人为构造的反例表明，对于近亲繁殖的家系，一些多余的基因型无法被排除。
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本文引用的文献
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Segregation analysis.分离分析
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