Liu Xia, Qiu Bin, Liu Wei, Zhang Yuhan, Wang Xianshu, Li Xingang, Li Lingfei, Zhang Di
Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong Academy of Agricultural Sciences, Jinan, China.
Front Nutr. 2022 Jun 16;9:940404. doi: 10.3389/fnut.2022.940404. eCollection 2022.
Diabetic kidney disease (DKD) is an important complication of diabetes. The prevention of DKD can effectively reduce the mortality rate of diabetic patients and improve their quality of life. The present study examined the effects of fermented and germinated foxtail millet whole grain (FG-FM) on kidney lesions in a diabetic mouse model (Db/Db mice). The results proved that the FG-FM consumption significantly alleviated the kidney tissue damage in the diabetic mouse model. The transcriptome analysis of kidney tissues demonstrated that the overactivation of signaling pathways related to inflammation and immunity in the diabetic mouse model was significantly inhibited with the FG-FM intake. Moreover, the consumption of the FG-FM diet effectively elevated the bacterial diversity, increased the relative abundance of probiotics and decreased the relative abundance of previously reported DKD-related bacteria in the gut microbiota of diabetic mice. Our study confirmed foxtail millet as a potential source of functional food for the non-pharmacological intervention of DKD.
糖尿病肾病（DKD）是糖尿病的一种重要并发症。预防DKD可有效降低糖尿病患者的死亡率并提高其生活质量。本研究检测了发酵发芽谷子全谷物（FG-FM）对糖尿病小鼠模型（Db/Db小鼠）肾脏病变的影响。结果证明，食用FG-FM可显著减轻糖尿病小鼠模型中的肾脏组织损伤。肾脏组织的转录组分析表明，摄入FG-FM可显著抑制糖尿病小鼠模型中与炎症和免疫相关信号通路的过度激活。此外，食用FG-FM饮食有效地提高了细菌多样性，增加了益生菌的相对丰度，并降低了糖尿病小鼠肠道微生物群中先前报道的与DKD相关细菌的相对丰度。我们的研究证实谷子是DKD非药物干预功能性食品的潜在来源。
