Jenabian Niloofar, Mohammadpour Sakine, Haghanifar Sina, Kazemi Sohrab, Hajiahmady Mahmood
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Dept. of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran.
J Dent (Shiraz). 2022 Jun;23(2):86-94. doi: 10.30476/DENTJODS.2021.84581.1090.
Molar teeth with furcation involvement are one of the most common problems in patients with periodontal disease. Regeneration methods are of the most controversial treatment strategies for these lesions.
The purpose of this study was to determine the effect of plasma rich in growth factors (PRGF) with 1.2% Atorvastatin (ATV) in the treatment of furcation involvement of mandibular molars.
The present randomized clinical trial was conducted on 15 patients with moderate periodontitis and class II furcation involvements; 24 defects were located in four groups of six, including debridement, ATV1.2%, PRGF, PRGF with ATV1.2%. The parameters of vertical probing depth (VPD), vertical clinical attachment level (VCAL), gingival index (GI), horizontal probing depth (HPD) and gingival recession (GR) were measured at baseline (T0), immediately before surgery (T1), 3 (T2), and 6 (T3) months after surgery. Moreover, the bone conditions were evaluated by digital subtraction radiography before and six months after surgery. Data were analyzed using SPSS23 software.
No significant difference in radiographic parameters was observed among the groups (= 0.08). There was no significant difference in the mean levels of VPD, VCAL and HPD among the groups at different times (<0.05). Comparison of clinical parameters of VPD, VCAL and GI in the treatment groups compared to the baseline showed a significant improvement in each group (< 0.05) but there was no significant difference among different groups (< 0.05).
The use of PRGF with ATV 1.2% in grade II furcation involvement in mandi-bular molars was effective in the improvement of clinical and radiographic parameters six months after treatment, but this effect revealed no difference in comparison with the other groups.
患有根分叉病变的磨牙是牙周病患者最常见的问题之一。对于这些病变，再生方法是最具争议的治疗策略之一。
本研究的目的是确定富含生长因子的血浆（PRGF）与1.2%阿托伐他汀（ATV）联合应用于治疗下颌磨牙根分叉病变的效果。
本随机临床试验对15例中度牙周炎且根分叉病变为II度的患者进行；24个缺损分为四组，每组6个，包括清创组、1.2%ATV组、PRGF组、PRGF与1.2%ATV联合组。在基线期（T0）、手术前即刻（T1）、术后3个月（T2）和6个月（T3）测量垂直探诊深度（VPD）、垂直临床附着水平（VCAL）、牙龈指数（GI）、水平探诊深度（HPD）和牙龈退缩（GR）等参数。此外，在手术前后通过数字减影放射摄影评估骨状况。使用SPSS23软件分析数据。
各组间影像学参数无显著差异（P = 0.08）。不同时间各组间VPD、VCAL和HPD的平均水平无显著差异（P>0.05）。与基线相比，治疗组VPD、VCAL和GI的临床参数比较显示每组均有显著改善（P<0.05），但不同组间无显著差异（P>0.05）。
1.2%ATV联合PRGF用于治疗下颌磨牙II度根分叉病变，在治疗6个月后对改善临床和影像学参数有效，但与其他组相比，这种效果无差异。
