Shao Yan, Yang Zhirong, Yin Lu, Wang Qiang, Wang Jie
Department of Cardiovascular Surgery, Qinghai Provincial People's Hospital, Xining, Qinghai, China.
Department of Cardiology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
Evid Based Complement Alternat Med. 2022 Jun 22;2022:5406649. doi: 10.1155/2022/5406649. eCollection 2022.
To investigate the clinical efficacy of cedilanid and isosorbide dinitrate plus pericardial dissection for chronic constrictive pericarditis in the elderly.
Ninety elderly patients with chronic constrictive pericarditis admitted to our hospital from March 2018 to October 2020 were recruited and assigned to receive either cedilanid and isosorbide dinitrate (control group A), pericardial dissection (control group B), or cedilanid and isosorbide dinitrate plus pericardial dissection (combination group) via random number table method, with 30 patients in each group. Outcome measures included plasma endothelin, atrial natriuretic peptide, system immune-inflammation indices, treatment effect, quality of life, mental state, and treatment satisfaction.
The combination group had significantly higher treatment satisfaction and treatment efficacy than control groups A and B ( > 0.05). The combination group showed the lowest levels of atrial natriuretic peptide and endothelin, followed by control group A, and group B ( < 0.001). The combined therapy resulted in significantly lower levels of system immunity index, lower Hospital Anxiety and Depression Scale (HAD) scores, and better General Quality of Life Inventory-74 (GQOLI-74) scores than those of the control group B, followed by group A ( < 0.001).
Cedilanid and isosorbide dinitrate plus pericardial dissection for elderly patients with chronic constrictive pericarditis enhances the level of plasma endothelin, atrial natriuretic peptide, and systemic immune-inflammation indexes of patients and improves their quality of life, which shows great potential for clinical promotion.
探讨毛花苷丙与硝酸异山梨酯联合心包剥离术治疗老年慢性缩窄性心包炎的临床疗效。
选取2018年3月至2020年10月我院收治的90例老年慢性缩窄性心包炎患者，采用随机数字表法将其分为毛花苷丙与硝酸异山梨酯组（A对照组）、心包剥离术组（B对照组）和毛花苷丙与硝酸异山梨酯联合心包剥离术组（联合组），每组30例。观察指标包括血浆内皮素、心钠素、全身免疫炎症指标、治疗效果、生活质量、精神状态及治疗满意度。
联合组的治疗满意度和治疗有效率显著高于A、B对照组（>0.05）。联合组的心钠素和内皮素水平最低，其次是A对照组，B对照组最高（<0.001）。联合治疗后患者的全身免疫炎症指标水平显著低于B对照组，医院焦虑抑郁量表（HAD）评分更低，生活质量综合评定问卷74（GQOLI-74）评分更高，其次是A对照组（<0.001）。
毛花苷丙与硝酸异山梨酯联合心包剥离术治疗老年慢性缩窄性心包炎可提高患者血浆内皮素、心钠素及全身免疫炎症指标水平，改善患者生活质量，具有较大的临床推广潜力。
