Zöller H
Klin Wochenschr. 1978 Aug 15;56(16):789-95. doi: 10.1007/BF01489711.
42 patients with minifest diabetes mellitus and 42 patients with primary hyperlipoproteinemia type II, IV or V (Fredickson) underwent analysis of cholesterol, triglycerides and agar-agarosegel-lipoprotein electrophoresis. Simultaneously clotting factors I--XIII, platelet count and aggregability, fibrinolytic activity and antithrombins were determined. The most accentuated disturbances were seen in hyperlipoproteinemia type II and in diabetes mellitus comprising increase of fibrinogen content, platelet reduction and enhanced platelet aggregability, hypofibrinolysis. Only minor differences of certain clotting factors could be detected comparing diabetes mellitus and hyperlipoproteinemia type II. Diabetes mellitus being complicated by micro- or macroangiopathia revealed additional significant alterations such as more pronounced increase of fibrinogen, further platelet reduction and aggregability. Increase of fibrinogen, platelt disturbances, hypofibrinolysis and alterations of antithrombin activity in connection with metabolic diseases may be regarded as additional risk to vascular complications.
42例轻度糖尿病患者和42例II型、IV型或V型（弗雷德里克森分型）原发性高脂蛋白血症患者接受了胆固醇、甘油三酯及琼脂 - 琼脂糖凝胶 - 脂蛋白电泳分析。同时测定了凝血因子I - XIII、血小板计数及聚集性、纤溶活性和抗凝血酶。在II型高脂蛋白血症和糖尿病中观察到最明显的紊乱，包括纤维蛋白原含量增加、血小板减少及血小板聚集性增强、纤溶减退。比较糖尿病和II型高脂蛋白血症时，仅发现某些凝血因子存在微小差异。合并微血管或大血管病变的糖尿病显示出额外的显著改变，如纤维蛋白原更明显增加、进一步的血小板减少及聚集性增强。与代谢性疾病相关的纤维蛋白原增加、血小板紊乱、纤溶减退及抗凝血酶活性改变可能被视为血管并发症的额外风险。
