Criqui M H, Lee E R, Hamburger R N, Klauber M R, Coughlin S S
Am J Med. 1987 May;82(5):964-8. doi: 10.1016/0002-9343(87)90159-8.
Because previous reports have suggested that IgE-mediated events may lead to both platelet activation and arterial spasm, a population-based study of 262 men and 315 women, aged 38 to 82, was conducted to investigate the association of serum IgE levels with myocardial infarction, stroke, and noninvasively diagnosed large-vessel peripheral arterial disease. In men with previous myocardial infarction, previous stroke, or current large-vessel peripheral arterial disease, geometric mean serum IgE levels were increased 119 percent, 164 percent, and 78 percent, respectively. These associations were statistically significant (p less than 0.05). Because IgE was positively or inversely correlated with several traditional cardiovascular disease risk factors, logistic regression was used to evaluate the independent association of IgE with any cardiovascular disease (myocardial infarction, stroke, or large-vessel peripheral arterial disease). In a model including age, cigarette smoking, fasting plasma glucose level, diastolic blood pressure, and low-density lipoprotein cholesterol level as covariates, IgE was positively and independently associated with any cardiovascular disease (p = 0.03). Similar evaluations in women revealed no correlation between IgE and cardiovascular disease by either univariate or multivariable analysis. These data indicate that IgE may be an independent marker for cardiovascular disease in men, and thus suggest IgE-mediated events may play a role in the pathogenesis of cardiovascular disease.
因为先前的报告表明，IgE介导的事件可能导致血小板活化和动脉痉挛，所以开展了一项基于人群的研究，纳入了262名男性和315名年龄在38至82岁之间的女性，以调查血清IgE水平与心肌梗死、中风以及非侵入性诊断的大血管外周动脉疾病之间的关联。在既往有心肌梗死、中风或当前患有大血管外周动脉疾病的男性中，血清IgE几何平均水平分别升高了119%、164%和78%。这些关联具有统计学意义（p小于0.05）。由于IgE与几种传统心血管疾病危险因素呈正相关或负相关，因此使用逻辑回归来评估IgE与任何心血管疾病（心肌梗死、中风或大血管外周动脉疾病）之间的独立关联。在一个将年龄、吸烟、空腹血糖水平、舒张压和低密度脂蛋白胆固醇水平作为协变量的模型中，IgE与任何心血管疾病呈正相关且独立相关（p = 0.03）。在女性中进行的类似评估显示，无论是单变量分析还是多变量分析，IgE与心血管疾病之间均无相关性。这些数据表明，IgE可能是男性心血管疾病的独立标志物，因此提示IgE介导的事件可能在心血管疾病的发病机制中起作用。
