Marouf Razan Salman, Mbarga Joseph Arsene M, Ermolaev Andrey V, Podoprigora Irina V, Smirnova Irina P, Yashina Natalia V, Zhigunova Anna V, Martynenkova Aliya V
Department of Microbiology and Virology, Institute of Medicine, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Department of Biochemistry, Institute of Medicine, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
J Pharm Bioallied Sci. 2022 Jan-Mar;14(1):1-12. doi: 10.4103/jpbs.jpbs_124_21. Epub 2022 May 19.
Urinary tract infections (UTIs) are one of the most common bacterial infections with uropathogenic (UPEC) being the most prevalent causative agent in both complicated and uncomplicated UTIs. Antibiotic resistance among UPEC has been already demonstrated against a wide variety of antibiotics and the situation is continuing to deteriorate increasing the rate of recurrence and the difficulty of treatment and prophylaxis. Recently, a big attention has been paid to non-antibiotic approaches as an alternative to conventional antibiotics. Among many strategies, phytotherapy has gained a special attention worldwide. Herbal remedies have been used in traditional medicine since ancient times and they are well known for their effectiveness in treating many health conditions including UTIs. Researches are conducted continuously to validate the use of many medicinal plants against UPEC, investigate their mechanisms of action, and determine their active constituents. Our extensive review of the recent literature revealed that many phytochemicals are shown to target and inhibit a wide variety of bioprocesses in UPEC, such as adhesion, motility, biofilm formation, and quorum sensing. Such natural approaches are very promising in confronting the antibiotic resistance of UPEC and can be further used to develop plant-based strategies and pharmaceutical products to treat and prevent UTIs caused by UPEC.
尿路感染（UTIs）是最常见的细菌感染之一，尿路致病性大肠杆菌（UPEC）是复杂性和非复杂性尿路感染中最普遍的病原体。UPEC对多种抗生素已表现出耐药性，且这种情况仍在继续恶化，导致复发率上升以及治疗和预防难度加大。最近，非抗生素方法作为传统抗生素的替代方案受到了广泛关注。在众多策略中，植物疗法在全球范围内受到了特别关注。草药疗法自古以来就在传统医学中使用，并且以其在治疗包括尿路感染在内的多种健康状况方面的有效性而闻名。人们持续进行研究以验证多种药用植物对UPEC的作用，探究其作用机制，并确定其活性成分。我们对近期文献的广泛综述表明，许多植物化学物质已显示出可靶向并抑制UPEC中的多种生物过程，如黏附、运动性、生物膜形成和群体感应。这种天然方法在应对UPEC的抗生素耐药性方面非常有前景，可进一步用于开发基于植物的策略和药品，以治疗和预防由UPEC引起的尿路感染。
