Hamdan Suzana, Surnar Bapurao, Kafkoutsou Alexia L, Magurno Luciano, Deo Sapna K, Jayaweera Dushyantha T, Dhar Shanta, Daunert Sylvia
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, United States.
Dr. JT Macdonald Foundation Biomedical Nanotechnology Institute of the University of Miami, Miami, Florida 33136, United States.
ACS Omega. 2022 Jun 14;7(25):21359-21369. doi: 10.1021/acsomega.1c05758. eCollection 2022 Jun 28.
Improved techniques were applied to formulate drugs into dimensional nanostructures, doped "nanovesicles". These nanovesicles are solely composed of self-assembled amphiphilic antiviral agents used for the treatment of viral infections caused by flaviviruses, such as Zika virus. Studies were done to evaluate the effectiveness of the syntheses, formation, and performance under different experimental conditions, and behavior of the drug nanovesicles and . These studies demonstrated that assembling the hydrophobic antiviral drug molecules into nanodrugs is a successful technique for the delivery of the therapeutic agents, otherwise difficult to be supplied. Our studies confirmed that this nanodrug preserved and, in many cases, enhanced the embedded cellular activity of the parental free drug molecules, both and . This proposed formulation is highly important as it addresses the issue of insolubility and low bioavailabiity of a wide range of highly potent pharmaceutical drugs-not limited to a specific class of antiviral drugs-that are of high demand for the treatment of medical conditions and emerging pathogens.
改进的技术被应用于将药物制成三维纳米结构，即掺杂的“纳米囊泡”。这些纳米囊泡仅由自组装的两亲性抗病毒剂组成，用于治疗由黄病毒引起的病毒感染，如寨卡病毒。开展了研究以评估在不同实验条件下合成、形成和性能的有效性，以及药物纳米囊泡的行为。这些研究表明，将疏水性抗病毒药物分子组装成纳米药物是一种成功的治疗剂递送技术，否则这些治疗剂难以供应。我们的研究证实，这种纳米药物保留了并在许多情况下增强了母体游离药物分子的内在细胞活性。这种提议的制剂非常重要，因为它解决了广泛的高效药物（不限于特定类别的抗病毒药物）的不溶性和低生物利用度问题，这些药物对于治疗医疗病症和新出现的病原体有很高需求。
