Li Xia, Guo Dianxuan, Zhou Wenhang, Hu Youdong, Zhou Hualan, Chen Ying
Xiamen Road Branch Hospital, 38044The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian, China.
Angiology. 2023 May;74(5):472-487. doi: 10.1177/00033197221111860. Epub 2022 Jul 4.
Pro-oxidative stress and pro-inflammatory responses can influence each other in the development of atherosclerosis. This study evaluated the relationship between oxidative stress, inflammation, and multiple peripheral artery occlusions in elderly patients (age mean 71.2 ± 8.1 years). A total of 723 participants were enrolled: 67 healthy subjects, 214 patients with common iliac artery occlusions, 224 patients with popliteal artery occlusions, and 218 patients with femoral artery occlusions. We measured oxidative stress biomarkers (malondialdehyde [MDA], F2-isoprostane [F2-isoP], total oxidant status [TOS], and ischemia-modified albumin [IMA]) and the expressions of molecules in mimecan (MIME)/nuclear factor kappa B (NF-κB)/P53/Toll-like receptor 4 (TLR4) signaling pathway in older patients with multiple peripheral artery occlusions. The levels of MDA, F2-isoP, TOS, IMA, MIME, NF-κB, P53, and TLR4 were increased in the single-site peripheral artery occlusive group when compared with healthy controls ( < .001) and were further increased in the multiple-site peripheral artery occlusive group compared with the single-site peripheral artery occlusive group ( < .001). Oxidative stress may promote inflammatory signaling pathways and lead to multiple peripheral artery occlusions in elderly patients.
促氧化应激和促炎反应在动脉粥样硬化的发展过程中可能相互影响。本研究评估了老年患者（平均年龄71.2±8.1岁）氧化应激、炎症与多发性外周动脉闭塞之间的关系。共纳入723名参与者：67名健康受试者、214名髂总动脉闭塞患者、224名腘动脉闭塞患者和218名股动脉闭塞患者。我们测量了多发性外周动脉闭塞老年患者的氧化应激生物标志物（丙二醛[MDA]、F2-异前列腺素[F2-isoP]、总氧化状态[TOS]和缺血修饰白蛋白[IMA]）以及 mimecan（MIME）/核因子κB（NF-κB）/P53/Toll样受体4（TLR4）信号通路中分子的表达。与健康对照组相比，单部位外周动脉闭塞组的MDA、F2-isoP、TOS、IMA、MIME、NF-κB、P53和TLR4水平升高（<0.001），与单部位外周动脉闭塞组相比，多部位外周动脉闭塞组的这些指标进一步升高（<0.001）。氧化应激可能促进炎症信号通路，并导致老年患者多发性外周动脉闭塞。
