CircRNAs：甲状腺癌诊断与治疗的新策略。

CircRNAs: A Novel Strategy in Diagnosis and Treatment of Thyroid Cancer.

机构信息

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. Iran.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Curr Mol Med. 2023;23(8):737-747. doi: 10.2174/1566524022666220701141914.

DOI:10.2174/1566524022666220701141914

PMID:35786335

Abstract

Thyroid cancer is one of the most frequent cancers globally, and its incidence has risen recently. The clinical behavior of thyroid cancer includes a wide range, from benign to invasive malignant tumors. Thus, precious diagnostic activities before therapeutic work are required. Circular RNAs (circRNAs) along with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are known as non-coding RNAs (ncRNAs). Large amounts of investigations have indicated that circRNAs can participate in multiple cellular processes, especially in tumorigenesis. Furthermore, circRNAs are stable in blood or plasma, as well as they are specific in different tissues. Therefore, they could serve as a potential diagnostic biomarker for cancer cells. Limited studies investigated the role of circRNAs in some processes involved in thyroid cancer. In this review, we summarized the current evidence on the potential clinical involvement of circRNAs in thyroid cancer.

摘要

甲状腺癌是全球最常见的癌症之一，其发病率最近有所上升。甲状腺癌的临床行为包括从良性到侵袭性恶性肿瘤的广泛范围。因此，在进行治疗工作之前需要进行宝贵的诊断活动。环状 RNA（circRNA）与 microRNAs（miRNA）和长非编码 RNA（lncRNA）一起被称为非编码 RNA（ncRNA）。大量研究表明，circRNA 可以参与多种细胞过程，特别是在肿瘤发生中。此外，circRNA 在血液或血浆中稳定，并且在不同组织中具有特异性。因此，它们可以作为癌细胞的潜在诊断生物标志物。有限的研究调查了 circRNA 在甲状腺癌涉及的某些过程中的作用。在这篇综述中，我们总结了目前关于 circRNA 在甲状腺癌中的潜在临床作用的证据。