Yang Lei, Luo Yang, Li Zhiyong
Lei Yang Department of Functional, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province 610000, P.R. China.
Yang Luo Department of Ultrasound, Chengdu First People's Hospital, Chengdu, Sichuan Province 610000, P.R. China.
Pak J Med Sci. 2025 Mar;41(3):848-855. doi: 10.12669/pjms.41.3.10566.
To evaluate the correlation between ultrasound (US) examination parameters and pathological characteristics of papillary thyroid carcinomas (PTC).
A retrospective analysis was conducted using clinical data from 89 patients with PTC (malignant group) and 89 patients with benign thyroid nodules (benign group) who underwent US at Chengdu Shuangliu Hospital of Traditional Chinese Medicine between February 2021 to February 2023. The correlation between ultrasound parameters and pathological features of PTC was analyzed.
Ultrasound parameters in the malignant group were significantly different from those in the benign group (<0.05). Peak systolic blood flow velocity (PSV), pulsation index (PI), and resistance index (RI) were significantly higher in patients with malignant lymph node metastasis (LNM) and stage III-IV PTC. In contrast, peak intensity (Peak), mean transit time (MTT), time to peak (TTP), and area under curve (AUC) were significantly lower than those in patients without LNM and stage I-II (<0.05). Spearman's analysis revealed significant correlations between ultrasound parameters, LNM, disease staging, and gene mutations (). Of the 89 PTC patients, 27 had disease recurrence, and five died during the follow-up. The poor prognosis group had significantly higher PSV, PI, and RI and lower Peak, MTT, TTP, and AUC compared to the good prognosis group (<0.05).
Ultrasound is a valuable tool for diagnosing and evaluating papillary thyroid carcinoma (PTC). It shows strong correlations between ultrasound parameters and pathological features, including lymph node metastasis and disease staging, aiding early diagnosis and prognosis prediction.
评估超声（US）检查参数与甲状腺乳头状癌（PTC）病理特征之间的相关性。
回顾性分析2021年2月至2023年2月在成都双流中医医院接受超声检查的89例PTC患者（恶性组）和89例甲状腺良性结节患者（良性组）的临床资料。分析PTC超声参数与病理特征之间的相关性。
恶性组超声参数与良性组有显著差异（<0.05）。恶性淋巴结转移（LNM）和III-IV期PTC患者的收缩期峰值血流速度（PSV）、搏动指数（PI）和阻力指数（RI）显著更高。相比之下，有LNM和I-II期患者的峰值强度（Peak）、平均通过时间（MTT）、达峰时间（TTP）和曲线下面积（AUC）显著更低（<0.05）。Spearman分析显示超声参数、LNM、疾病分期和基因突变之间存在显著相关性（）。89例PTC患者中，27例疾病复发，5例在随访期间死亡。与预后良好组相比，预后不良组的PSV、PI和RI显著更高，而Peak、MTT、TTP和AUC更低（<0.05）。
超声是诊断和评估甲状腺乳头状癌（PTC）的有价值工具。它显示超声参数与病理特征之间有很强的相关性，包括淋巴结转移和疾病分期，有助于早期诊断和预后预测。
