Georges M C, Roure C, Tauxe R V, Meunier D M, Merlin M, Testa J, Baya C, Limbassa J, Georges A J
Am J Trop Med Hyg. 1987 May;36(3):598-602. doi: 10.4269/ajtmh.1987.36.598.
Diarrheal morbidity and mortality in children less than 5 years old were studied in Bangui, Central African Republic, by a cluster survey. We found a high prevalence of diarrheal disease with an estimated annual incidence of 7 episodes of diarrhea per child per year. The estimated annual mortality rate for children less than 5 years old was 28.6 per 1,000 and 85.8 per 1,000 for infants; 51.6% of deaths were reported to be associated with diarrhea. During the survey, stool specimens were collected from 133 children with current diarrhea and 117 control children to study the etiologic agents of diarrheal disease in the community. An enteric pathogen was identified in 58% of diarrheal children's stools and 48% of stools of well children. A statistically significant association between diarrhea and rotavirus was found, with it being isolated from 8 of 33 (24%) of stools of infants with diarrhea compared to 0 of 25 (0%) of control infants. Isolation rates for Campylobacter jejuni, Entamoeba histolytica, pathogenic Escherichia coli, and other bacterial enteropathogens did not differ significantly between children with diarrhea and control children.
通过整群抽样调查，对中非共和国班吉市5岁以下儿童的腹泻发病率和死亡率进行了研究。我们发现腹泻病的患病率很高，估计每年每名儿童腹泻发作7次。5岁以下儿童的估计年死亡率为每1000人28.6例，婴儿为每1000人85.8例；据报告，51.6%的死亡与腹泻有关。在调查期间，从133名患有腹泻的儿童和117名对照儿童中采集了粪便样本，以研究社区腹泻病的病原体。在58%的腹泻儿童粪便和48%的健康儿童粪便中发现了肠道病原体。腹泻与轮状病毒之间存在统计学上的显著关联，腹泻婴儿的33份粪便中有8份（24%）分离出轮状病毒，而对照婴儿的25份粪便中未分离出（0%）。空肠弯曲菌、溶组织内阿米巴、致病性大肠杆菌和其他细菌性肠道病原体的分离率在腹泻儿童和对照儿童之间没有显著差异。
