Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Medicine, University of California San Francisco, School of Medicine, San Francisco, CA 94143, USA.
Biomark Med. 2022 Aug;16(11):839-846. doi: 10.2217/bmm-2021-0596. Epub 2022 Jul 5.
Lysil oxidase like enzyme-2 (LOXL-2) and TNC-C play important roles in organ fibrosis. We assessed circulating LOXL-2 and TNC-C levels and their relationship to fibrosis severity in HIV- and/or HCV-infected individuals. Healthy controls (n = 22), HIV mono- (n = 15), HCV mono- (n = 52) and HCV/HIV-co-infected (n = 92) subjects were included. LOXL-2 and TNC-C levels were significantly higher in HCV mono- and HCV/HIV-co-infected individuals with F0 compared to healthy controls. In addition, in HCV/HIV-co-infected individuals, LOXL-2 levels were higher in intermediate fibrosis compared to no/mild fibrosis. In HCV/HIV-co-infected study participants, both LOXL-2 and TNC-C were significantly higher in intermediate fibrosis compared to no/mild fibrosis, but did not further increase with advanced fibrosis. Furthermore, both markers were elevated among HCV/HIV-positive individuals with mild/no fibrosis.
赖氨酰氧化酶样酶 2（LOXL-2）和 TNC-C 在器官纤维化中发挥重要作用。我们评估了 HIV-和/或 HCV 感染个体中循环 LOXL-2 和 TNC-C 水平及其与纤维化严重程度的关系。纳入了健康对照组（n=22）、HIV 单感染组（n=15）、HCV 单感染组（n=52）和 HCV/HIV 共感染组（n=92）。与健康对照组相比，HCV 单感染和 HCV/HIV 共感染的 F0 个体中 LOXL-2 和 TNC-C 水平显著升高。此外，在 HCV/HIV 共感染个体中，与无/轻度纤维化相比，中纤维化个体的 LOXL-2 水平更高。在 HCV/HIV 共感染研究参与者中，与无/轻度纤维化相比，中纤维化患者的 LOXL-2 和 TNC-C 均显著升高，但随着纤维化程度的加重，其水平并未进一步升高。此外，轻度/无纤维化的 HCV/HIV 阳性个体中这两种标志物均升高。
