基于吡虫啉的商业杀虫剂会导致Wistar大鼠出现行为、生化和血液学损伤。
Imidacloprid-based commercial pesticide causes behavioral, biochemical, and hematological impairments in Wistar rats.
作者信息
Tonietto Bruna Ducatti, Laurentino Ana Olívia Martins, Costa-Valle Marina Tuerlinckx, Cestonaro Larissa Vivan, Antunes Bibiana Pereira, Sates Cleofas, Dos Santos Nícolas Guimarães, Dallegrave Eliane, Garcia Solange Cristina, Leal Mirna Bainy, Arbo Marcelo Dutra
机构信息
Laboratório de Toxicologia (LATOX), Departamento de Análises, Faculdade de Farmácia - Anexo I, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Laboratório de Farmacologia e Toxicologia Neurocomportamental, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil.
出版信息
Environ Toxicol Pharmacol. 2022 Aug;94:103924. doi: 10.1016/j.etap.2022.103924. Epub 2022 Jul 3.
Imidacloprid (IMI) is a neonicotinoid insecticide employed worldwide for crop protection. IMI's mode of action occurs through the agonism of postsynaptic nicotinic acetylcholine receptors (nAChRs), with high specificity for insect nAChRs although there are reports of mammals' toxicity. Studies on IMI's neurotoxicity are not conclusive; therefore, the aim of this study was to evaluate the subchronic toxic effects of an IMI based commercial pesticide on rats. Adult male Wistar rats received an IMI suspension via the oral route at doses of 1.5, 5, and 15 mg/kg for 45 consecutive days. IMI caused an increase in rearing and time spent at the periphery in the locomotor activity test and a decrease in time spent to finish the OX maze task (p < 0.05; ANOVA/Bonferroni). In blood, there was a decrease in mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (p < 0.05; ANOVA/Bonferroni) and an increase in serum butyrylcholinesterase activity (p < 0.001; ANOVA/Bonferroni). Therefore, subchronic administration of an IMI-based-pesticide caused behavioral and systemic impairments in rats.
吡虫啉（IMI）是一种在全球范围内用于作物保护的新烟碱类杀虫剂。IMI的作用方式是通过对突触后烟碱型乙酰胆碱受体（nAChRs）的激动作用实现的，它对昆虫nAChRs具有高度特异性，不过也有关于其对哺乳动物毒性的报道。关于IMI神经毒性的研究尚无定论；因此，本研究的目的是评估一种基于IMI的商业杀虫剂对大鼠的亚慢性毒性作用。成年雄性Wistar大鼠连续45天经口接受剂量为1.5、5和15毫克/千克的IMI悬浮液。在运动活动测试中，IMI导致大鼠竖毛次数增加、在周边区域停留时间延长，并且完成OX迷宫任务的时间减少（p < 0.05；方差分析/邦费罗尼检验）。血液方面，平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度降低（p < 0.05；方差分析/邦费罗尼检验），血清丁酰胆碱酯酶活性增加（p < 0.001；方差分析/邦费罗尼检验）。因此，亚慢性给予基于IMI的杀虫剂会导致大鼠出现行为和全身功能障碍。
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