Liu Xiaojie, Zhao Di, Wu Xiaoling, Zhao Sijun, Li Zhenyu, Qin Xuemei
Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China; The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China; Institute of Biomedicine and Health, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China.
Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China; The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China; Institute of Biomedicine and Health, Shanxi University, No. 92, Wucheng Rd., Xiaodian Dist., Taiyuan 030006, Shanxi, China.
Exp Gerontol. 2022 Sep;166:111882. doi: 10.1016/j.exger.2022.111882. Epub 2022 Jul 1.
Aging is a complex physiological process associated with degenerative disorders of metabolism and intestinal flora. Constipation is an age-dependent gastrointestinal disease, which is involved in several diseases, such as cardiovascular and cerebrovascular diseases, colon cancer, etc. Gut microbiota is involved in both aging and constipation, which is probably through metabolism. Yet, the underlying mechanisms are still unclear. Our findings showed significant changes in the cecum microbiome compositions across aging and constipation, and the community composition is similar in both. A cluster analysis demonstrated that the key gut bacteria associated with aging and the key gut bacteria associated with constipation were clustered together. Function analysis explored the associations between both via specific gut bacteria's metabolism pathways, involving in 8 metabolic pathways. Associated networks showed that not only gut microbial metabolites are important signaling molecules associated with aging and constipation, but also the occurrence and the development of senescence and constipation are affected at multiple levels and by multiple factors. In this study, both macro and micro indexes, and traditional and modern indexes are combined to prove the important regulatory roles of intestinal microorganisms in aging and constipation, and systematically elaborated the fact that constipation and aging are mutual causation and mutual influences.
衰老 是 一个 与 代谢 和 肠道 菌群 退行性 疾病 相关 的 复杂 生理 过程。便秘 是 一种 与 年龄 相关 的 胃肠道 疾病，它 与 多种 疾病 有关，如 心血管 和 脑血管 疾病、结肠癌 等。肠道 微生物群 参与 衰老 和 便秘 过程，这 可能 是 通过 代谢 实现 的。然而，其 潜在 机制 仍 不 清楚。我们 的 研究 结果 表明，在 衰老 和 便秘 过程中 盲肠 微生物群 组成 发生 了 显著 变化，且 两者 的 群落 组成 相似。聚类 分析 表明，与 衰老 相关 的 关键 肠道 细菌 和 与 便秘 相关 的 关键 肠道 细菌 聚集 在 一起。功能 分析 通过 特定 肠道 细菌 的 代谢 途径 探索 了 两者 之间 的 关联，涉及 8 条 代谢 途径。关联 网络 表明，不仅 肠道 微生物 代谢产物 是 与 衰老 和 便秘 相关 的 重要 信号 分子，而且 衰老 和 便秘 的 发生 和 发展 在 多个 层面 受到 多种 因素 的 影响。在 本 研究 中，结合 宏观 和 微观 指标 以及 传统 和 现代 指标，证明 了 肠道 微生物 在 衰老 和 便秘 中的 重要 调节 作用，并 系统 阐述 了 便秘 和 衰老 相互 因果、相互 影响 的 事实。
