Gingerich R L, Gersell D J, Greider M H, Finke E H, Lacy P E
Metabolism. 1978 Oct;27(10):1526-32. doi: 10.1016/s0026-0495(78)80025-0.
The concentration and distribution of pancreatic polypeptide (PP) was studied in hyperglycemic obese (ob/ob) mice and homozygous (+/+) controls. By radioimmunoassay, the concentration of PP in the pancreas of ob/ob mice was greater both in the duodenal lobe (70.7%) and in the body and tail (66.3%) when compared to identical areas of control pancreases. Analysis of immunostained pancreatic tissue indicated that the number of PP cells per islet cross-section was significantly increased (58%) in the ob/ob tissue. The calculated total number of PP cells per average islet was elevated three times in the ob/ob islet. However, the proportion PP cell volume relative to the islet volume in ob/ob was one-half that of control islets. These results clearly demonstrate an elevation in both the number of PP cells per islet and the concentration of PP in the diabetic ob/ob murine pancreas.
研究了高血糖肥胖（ob/ob）小鼠和纯合子（+/+）对照小鼠中胰多肽（PP）的浓度和分布。通过放射免疫分析，与对照胰腺的相同区域相比，ob/ob小鼠胰腺十二指肠叶（70.7%）以及体部和尾部（66.3%）的PP浓度更高。对免疫染色的胰腺组织分析表明，ob/ob组织中每个胰岛横截面的PP细胞数量显著增加（58%）。计算得出，ob/ob胰岛中每个平均胰岛的PP细胞总数增加了两倍。然而，ob/ob中PP细胞体积相对于胰岛体积的比例是对照胰岛的一半。这些结果清楚地表明，糖尿病ob/ob小鼠胰腺中每个胰岛的PP细胞数量和PP浓度均有所升高。
