O'Connor Reed M, Scott Marla E, Bakkar Rania, Rimel B J
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA.
Gynecol Oncol Rep. 2022 Jun 17;42:101031. doi: 10.1016/j.gore.2022.101031. eCollection 2022 Aug.
Testosterone is commonly used as gender-affirming therapy to induce masculinization in transmasculine individuals. The effects of testosterone therapy on endometrial tissue are complex, and while some patients experience endometrial atrophy while taking testosterone, others do not. Reports of gynecologic malignancies, and endometrial cancer in particular, in transmasculine patients taking testosterone are extremely rare (Urban et al., May 2011, Jeevananthan and Iyengar, 2021, Agnieszka Bobola, 2021). Here we report a case of endometrial intraepithelial neoplasia in a transgender man taking testosterone.
睾酮通常用作性别肯定疗法，以促使跨性别男性个体男性化。睾酮疗法对子宫内膜组织的影响较为复杂，虽然一些患者在服用睾酮时会出现子宫内膜萎缩，但另一些患者则不会。服用睾酮的跨性别男性患者发生妇科恶性肿瘤，尤其是子宫内膜癌的报告极为罕见（厄本等人，2011年5月；吉万南丹和伊延加尔，2021年；阿格涅什卡·博博拉，2021年）。在此，我们报告一例服用睾酮的跨性别男性发生子宫内膜上皮内瘤变的病例。
