Amsterdam UMC location VUmc, Department of Obstetrics and Gynaecology, De Boelelaan 1117, Amsterdam HV 1081, the Netherlands; Amsterdam UMC location VUmc, Centre of Expertise on Gender Dysphoria, De Boelelaan 1117, Amsterdam HV 1081, the Netherlands; Vrije Universiteit Amsterdam, Amsterdam Reproduction and Development research institute, De Boelelaan 1085, Amsterdam HV 1081, the Netherlands.
Amsterdam UMC location VUmc, Department of Obstetrics and Gynaecology, De Boelelaan 1117, Amsterdam HV 1081, the Netherlands.
Reprod Biomed Online. 2022 Nov;45(5):1033-1038. doi: 10.1016/j.rbmo.2022.06.012. Epub 2022 Jun 22.
What is the endometrial thickness of endometrium exposed to testosterone in transmasculine people compared with unexposed endometrium in cisgender women as determined by transvaginal ultrasound (TVU)?
Single centre, cross-sectional cohort study conducted the Centre of Expertise on Gender Dysphoria in Amsterdam. Between 2013 and 2015, transmasculine people scheduled for gender affirming surgery (GAS) were included in this study after they provided informed consent. They were undergoing gender affirming hormone therapy (testosterone) for at least 1 year. Endometrial thickness (mm) was measured by TVU in transmasculine people, immediately before their GAS while under general anaesthesia. Cisgender control women from the general population underwent the exact same TVU measurements in an outpatient clinical setting on cycle days 2-5.
Fifty-one transmasculine people and 77 controls were included. The mean duration of testosterone use was 30.2 months (SD 8.8). Endometrial thickness was significantly lower in transmasculine people compared with cisgender women: median 3.9 mm (interquartile range [IQR] 2.8-5.1) and 4.9 mm (IQR 4.0-6.3), respectively (P < 0.001), after correcting for confounding factor (current gonadotrophin releasing hormone agonist use).
Endometrial thickness in transmasculine people exposed to testosterone is significantly lower compared with cisgender women without testosterone exposure. These results suggest an absence of endometrial proliferation by exogenous testosterone.
经阴道超声（TVU）检查，与未暴露于睾酮的顺性别女性子宫内膜相比，暴露于睾酮的跨性别男性的子宫内膜厚度如何？
这项单中心、横断面队列研究在阿姆斯特丹性别认同障碍专业中心进行。2013 年至 2015 年，在提供知情同意后，计划接受性别肯定手术（GAS）的跨性别男性被纳入本研究。他们正在接受至少 1 年的性别肯定激素治疗（睾酮）。在全身麻醉下，跨性别男性在接受 GAS 之前，通过 TVU 测量子宫内膜厚度（mm）。来自普通人群的顺性别对照女性在门诊临床环境中在周期第 2-5 天进行相同的 TVU 测量。
共纳入 51 名跨性别男性和 77 名对照。睾酮使用的平均持续时间为 30.2 个月（SD 8.8）。经混杂因素（当前促性腺激素释放激素激动剂使用）校正后，跨性别男性的子宫内膜厚度明显低于顺性别女性：中位数分别为 3.9mm（IQR 2.8-5.1）和 4.9mm（IQR 4.0-6.3）（P<0.001）。
与未暴露于睾酮的顺性别女性相比，暴露于睾酮的跨性别男性的子宫内膜厚度明显较低。这些结果表明外源性睾酮不存在子宫内膜增殖。
