Takeshima Kazumi, Ezoe Kenji, Kawasaki Nami, Hayashi Hiroko, Kuroda Tomoko, Kato Keiichi
Kato Ladies Clinic, Tokyo, Japan.
F S Rep. 2022 Mar 6;3(2):138-144. doi: 10.1016/j.xfre.2022.03.001. eCollection 2022 Jun.
To investigate and compare the safety of letrozole and natural cycles in fresh early embryo transfers.
A retrospective cohort study.
A large fertility treatment center.
Women who underwent natural and letrozole cycles during fresh early embryo transfer at Kato Ladies Clinic between January 2008 and December 2017.
None.
Perinatal complications and congenital anomalies.
No significant differences were observed in pregnancy complications, gestational age, birth weight, small for gestational age, large for gestational age, and congenital anomalies between the the women who underwent natural and letrozole cycles.
The perinatal outcomes and congenital anomaly rates associated with letrozole and natural cycles in fresh early embryo transfers were comparable. Therefore, our data support the safe use of letrozole in fresh early embryo transfers in assisted reproductive technology.
探讨并比较来曲唑和自然周期在新鲜早期胚胎移植中的安全性。
一项回顾性队列研究。
一家大型生育治疗中心。
2008年1月至2017年12月期间在加藤女士诊所接受新鲜早期胚胎移植的自然周期和来曲唑周期的女性。
无。
围产期并发症和先天性异常。
接受自然周期和来曲唑周期的女性在妊娠并发症、孕周、出生体重、小于胎龄儿、大于胎龄儿和先天性异常方面未观察到显著差异。
新鲜早期胚胎移植中来曲唑和自然周期相关的围产期结局和先天性异常率具有可比性。因此，我们的数据支持在辅助生殖技术的新鲜早期胚胎移植中来曲唑的安全使用。
