Fasakin Olamide Wilson, Oboh Ganiyu, Ademosun Ayokunle Olubode
Functional Foods, Nutraceuticals and Phytomedicine Unit, Department of Biochemistry, Federal University of Technology, P.M.B. 704, Akure, 340001 Nigeria.
Comp Clin Path. 2022;31(5):853-873. doi: 10.1007/s00580-022-03374-w. Epub 2022 Jun 28.
and are plants that naturally grow in Nigeria. They are reportedly rich in neuroactive compounds that are capable of reacting with the nervous system to elicit psychoactive and/or toxic effects that deter predators. However, despite the toxicological potential of these plants, their recreational use is on the rise due to the psychoactivity they proffer and prevalence in Nigeria. The aim of the present study is to evaluate the plants' recreational use, mechanism of actions and toxicities. Relevant published documents on psychoactive plants in Nigeria were obtained from Web of Science between 2002 and 2020. Non-English documents, documents not in Science Citation Index Expanded and Google Scholar were removed while 1186 documents were reviewed. Results showed that the plants are recreationally used in Nigeria with a higher prevalence than the global frequency. They are very addictive and lead to dependence. The plants were also observed to elicit different mechanism of action, though the activation of monoaminergic neurotransmission system was common to all. Regrettably, the plants could be toxic when ingested under non-medical conditions. Conclusively, these plants are addictive with potential toxic effects. Therefore, control of the recreational use of these plants should be revamped and overhauled.
[植物名称1]和[植物名称2]是自然生长在尼日利亚的植物。据报道，它们富含神经活性化合物，这些化合物能够与神经系统发生反应，引发精神活性和/或毒性作用，从而威慑捕食者。然而，尽管这些植物具有毒理学潜力，但由于它们所提供的精神活性以及在尼日利亚的广泛存在，其用于娱乐目的的情况却在增加。本研究的目的是评估这些植物用于娱乐的情况、作用机制和毒性。2002年至2020年间，从科学网获取了尼日利亚有关精神活性植物的相关已发表文献。剔除了非英文文献、未被科学引文索引扩展版收录的文献以及谷歌学术上的文献，共审查了1186篇文献。结果表明，这些植物在尼日利亚被用于娱乐，其流行程度高于全球平均水平。它们极易成瘾并会导致依赖。还观察到这些植物会引发不同的作用机制，尽管单胺能神经传递系统的激活是它们共有的。遗憾的是，在非医疗条件下摄入这些植物可能会有毒性。总之，这些植物具有成瘾性并具有潜在毒性作用。因此，应重新审视并全面改革对这些植物娱乐性使用的管控。
