Zhumadian Academy of Industry Innovation and Development, Huanghuai University, Zhumadian, China.
School of Biological and Food Processing Engineering, Huanghuai University, Zhumadian, China.
Expert Rev Anti Infect Ther. 2022 Sep;20(9):1217-1231. doi: 10.1080/14787210.2022.2098114. Epub 2022 Jul 13.
O1/O139 is responsible for cholera epidemics that remains a huge public health menace across the globe. Furthermore, an increasing resistance rate among strains has been reported around the world. Therefore, the objective of this meta-analysis was to evaluate the weighted pooled resistance (WPR) rates in clinical O1/O139 isolates based on different years, areas, antimicrobial susceptibility testing, and resistance rates.
We searched the studies in PubMed, Scopus, Embase, and Web of Science (until January 2020). Statistical analyses were conducted using STATA software (ver. 14.0).
A total of 139 studies investigating 24,062 O1/O139 isolates were analyzed. The majority of the studies originated in Asia ( = 102). The WPR rates were as follows: azithromycin 1%, erythromycin 36%, ciprofloxacin 3%, cotrimoxazole 79%, doxycycline 7%, and tetracycline 20%. There was increased resistance to cotrimoxazole, ciprofloxacin, and tetracycline during the 1980-2020 years.
Temporal changes in antibiotic resistance rate found in this study demonstrated the critical continuous surveillance of antibiotic resistance. Also, ciprofloxacin, azithromycin, gentamicin, cephalexin, imipenem, ofloxacin, and norfloxacin were found to be the best antibiotics against , with the highest and the lowest effectiveness resistance rate.
O1/O139 血清型霍乱弧菌仍然是全球范围内的一个巨大的公共卫生威胁。此外，世界各地报道的菌株耐药率呈上升趋势。因此，本荟萃分析的目的是评估基于不同年份、地区、抗菌药物敏感性试验和耐药率的临床 O1/O139 分离株的加权总耐药率（WPR）。
我们在 PubMed、Scopus、Embase 和 Web of Science（截至 2020 年 1 月）中搜索了研究。使用 STATA 软件（版本 14.0）进行统计分析。
共分析了 139 项研究的 24062 株 O1/O139 分离株。大多数研究来自亚洲（=102）。WPR 率如下：阿奇霉素 1%、红霉素 36%、环丙沙星 3%、复方磺胺甲噁唑 79%、强力霉素 7%和四环素 20%。在 1980 年至 2020 年期间，对复方磺胺甲噁唑、环丙沙星和四环素的耐药性增加。
本研究中抗生素耐药率的时间变化表明，对抗生素耐药性的持续监测至关重要。此外，发现环丙沙星、阿奇霉素、庆大霉素、头孢氨苄、亚胺培南、氧氟沙星和诺氟沙星是针对霍乱弧菌的最佳抗生素，其有效性耐药率最高，最低。
