Department of Ophthalmology, Akdeniz University Hospital, Antalya, Turkey.
Department of Ophthalmology, Antalya Manavgat State Hospital, 07600, Antalya, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2022 Dec;260(12):3919-3925. doi: 10.1007/s00417-022-05749-9. Epub 2022 Jul 6.
To analyze the postoperative foveal avascular zone (FAZ) area, superficial capillary plexus (SCP), deep capillary plexus (DCP) vascular densities (VD), and retinal layers after cross-linking (CXL) for keratoconus treatment.
Twenty-seven eyes with cross-linking treatment for keratoconus were included in the study. Foveal avascular zone (FAZ) area, SCP VD, DCP VD, and retinal layers were evaluated by using optical coherence tomography angiography (OCTA). OCTA measurements were made at preoperative, first week, and first and sixth months after the surgery. In addition, corneal topography measurements were also made.
Although there was a decrease in corneal thickness in the follow-up of the patients, there was no significant difference in axial length and anterior chamber depth. There was no significant difference in full retinal thickness in the foveal and parafoveal areas. While there was a significant increase in retinal nerve fiber layer (RNFL) thickness in the foveal area (p = 0.032, p = 0.015, p = 0.017; preoperative values compared to first week, first month, and sixth month respectively), there was a decrease in ganglion cell layer (GCL) thickness in the parafoveal area in the postoperative sixth month (p = 0.028). There was no difference in FAZ measurements. In the parafoveal area, a decrease was observed in SCP VD in the sixth-month control (p = 0.019). There was a significant increase in DCP VD in the foveal area (p = 0.008, p = 0.043, p = 0.040). The preoperative mean CDVA (corrected distance visual acuity) was 0.37 ± 0.16 logMAR and postoperative sixth month mean CDVA was 0.39 ± 0.15. There was no significant difference in visual acuity (p = 0.71).
Keratoconus patients successfully treated with CXL had significant changes in retinal layers and vessel density in the superficial and deep retinal plexus.
分析交联治疗圆锥角膜术后中心凹无血管区（FAZ）面积、浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）血管密度（VD）和视网膜层。
本研究纳入 27 例接受交联治疗的圆锥角膜患者。使用光学相干断层扫描血管造影术（OCTA）评估中心凹无血管区（FAZ）面积、SCP VD、DCP VD 和视网膜层。在术前、术后第 1 周和第 1、6 个月进行 OCTA 测量。此外，还进行了角膜地形图测量。
虽然患者的角膜厚度在随访中有所下降，但眼轴和前房深度无显著差异。中心凹和旁中心凹的全视网膜厚度无显著差异。虽然中心凹区域的视网膜神经纤维层（RNFL）厚度显著增加（p=0.032，p=0.015，p=0.017；与术前相比，分别为第 1 周、第 1 个月和第 6 个月），但旁中心凹区域的节细胞层（GCL）厚度在术后第 6 个月下降（p=0.028）。FAZ 测量无差异。在旁中心凹区域，第六个月的 SCP VD 降低（p=0.019）。中心凹区域的 DCP VD 显著增加（p=0.008，p=0.043，p=0.040）。术前平均 CDVA（矫正距离视力）为 0.37±0.16 logMAR，术后第六个月平均 CDVA 为 0.39±0.15。视力无显著差异（p=0.71）。
成功接受 CXL 治疗的圆锥角膜患者的视网膜层和浅层及深层视网膜丛的血管密度均发生显著变化。
