Farzaneh Maryam, Najafi Sajad, Anbiyaee Omid, Azizidoost Shirin, Khoshnam Seyed Esmaeil
Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Transl Oncol. 2023 Jan;25(1):21-32. doi: 10.1007/s12094-022-02876-x. Epub 2022 Jul 6.
Osteosarcoma (OS) is a common and malignant form of bone cancer, which affects children and young adults. OS is identified by osteogenic differentiation and metastasis. However, the exact molecular mechanism of OS development and progression is still unclear. Recently, long non-coding RNAs (lncRNA) have been proven to regulate OS proliferation and drug resistance. LncRNAs are longer than 200 nucleotides that represent the extensive applications in the processing of pre-mRNA and the pathogenesis of human diseases. Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) is a well-known lncRNA known as a transcriptional and translational regulator. The aberrant expression of MALAT1 has been shown in several human cancers. The high level of MALAT1 is involved in OS cell growth and tumorigenicity by targeting several signaling pathways and miRNAs. Hence, MALAT1 might be a suitable approach for OS diagnosis and treatment. In this review, we will summarize the role of lncRNA MALAT1 in the pathophysiology of OS.
骨肉瘤（OS）是一种常见的恶性骨癌，影响儿童和年轻人。骨肉瘤通过成骨分化和转移来识别。然而，骨肉瘤发生和发展的确切分子机制仍不清楚。最近，长链非编码RNA（lncRNA）已被证明可调节骨肉瘤的增殖和耐药性。lncRNA长度超过200个核苷酸，在信使前体核糖核酸（pre-mRNA）加工和人类疾病发病机制中具有广泛应用。转移相关的肺腺癌转录本1（MALAT1）是一种著名的lncRNA，作为转录和翻译调节因子。MALAT1的异常表达已在几种人类癌症中得到证实。高水平的MALAT1通过靶向多种信号通路和微小RNA（miRNA）参与骨肉瘤细胞生长和致瘤性。因此，MALAT1可能是骨肉瘤诊断和治疗的合适方法。在本综述中，我们将总结lncRNA MALAT1在骨肉瘤病理生理学中的作用。
