[实验性膀胱乙状结肠造口术的生化并发症]

[Biochemical complications of experimental vesico-sigmoidostomy].

作者信息

Nuñez R, Blesa E, Ramos S, Morillo M, Ortega L, Requena F, Cardesa J J

出版信息

An Esp Pediatr. 1987 Mar;26(3):209-14.

Abstract

Three experimental models of vesico-sigmoidostomy are studied (model-1, end to side V-S plus urethral ligation, model-2, end to end V-S, in "Y of Rous" plus urethral ligation and model-3, vesico-sigmoidoplasty), with aim of reproducing chemical imbalance observed in human subjects with ureterosigmoidostomy. Authors have evaluated clinical biochemical (serum acido-base balance, Cl, Na+, K+, BUN, creatinine, ammonia and albumin), and histologic variables in the first, third and fifth month after operation in 225 rats. Animal of model-1 presented more frequently than model-2 and model-3, alterations (hyperchloraemic acidosis, uraemia, hyperammonemia and hypoalbumin) as well as affectation of upper urinary system for acute or chronic pyelonephritis.

摘要

研究了三种膀胱乙状结肠造口术的实验模型（模型1，端侧膀胱乙状结肠造口术加尿道结扎；模型2，端端膀胱乙状结肠造口术，呈“鲁氏Y形”加尿道结扎；模型3，膀胱乙状结肠成形术），目的是再现输尿管乙状结肠造口术患者中观察到的化学失衡。作者评估了225只大鼠术后第1、3和5个月的临床生化指标（血清酸碱平衡、氯、钠、钾、尿素氮、肌酐、氨和白蛋白）以及组织学变量。模型1的动物比模型2和模型3更频繁地出现改变（高氯性酸中毒、尿毒症、高氨血症和低白蛋白血症）以及上尿路因急性或慢性肾盂肾炎而受到影响。