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Motor deficits seen in microglial ablation mice could be due to non-specific damage from high dose diphtheria toxin treatment.

作者信息

Peng Jiyun, Zou Qian, Chen Min-Jie, Ma Chao-Lin, Li Bao-Ming

机构信息

Institute of Life Science, Nanchang University, 330031, Nanchang, China.

Department of Physiology and Institute of Brain Science, School of Basic Medical Sciences, Hangzhou Normal University, 311121, Hangzhou, China.

出版信息

Nat Commun. 2022 Jul 5;13(1):3874. doi: 10.1038/s41467-022-31562-3.

DOI:10.1038/s41467-022-31562-3
PMID:35790742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9256727/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/9256727/c99664e0fa34/41467_2022_31562_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/9256727/129d754b7a41/41467_2022_31562_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/9256727/c99664e0fa34/41467_2022_31562_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/9256727/129d754b7a41/41467_2022_31562_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1246/9256727/c99664e0fa34/41467_2022_31562_Fig2_HTML.jpg

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Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion.
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