Department of Radiology, Affiliated Hospital of Yunnan University, The Second People's Hospital of Yunnan Province, No.176 of Qingnian street, Wuhua District, Kunming, 650000, China.
BMC Med Imaging. 2022 Jul 5;22(1):121. doi: 10.1186/s12880-022-00846-x.
The aims of this study were to evaluate the levels of preretinal oxygen tension in patients with diabetes who did not have hypertension by using three-dimensional spoiled gradient-recalled (3D-SPGR) echo sequence imaging and to explore the correlation between diabetic retinopathy (DR) and changes in preretinal oxygen tension.
This study involved 15 patients with type 2 diabetes without hypertension, who were divided into a diabetic retinopathy (DR) group (n = 10 eyes) and a diabetic non-retinopathy (NDR) group (n = 20 eyes), according to the results of a fundus photography test. Another healthy control group (n = 14 eyes) also participated in the study. The preretinal vitreous optic disc area, nasal side, and temporal side signal intensity of the eyes was assessed before and after oxygen inhalation with the use of 3D-SPGR echo magnetic resonance imaging (MRI). The signal acquisition time was 10, 20, 30, 40, and 50 min after oxygen inhalation.
The results showed that, in the DR and NDR groups, the preretinal vitreous oxygen tension increased rapidly at 10 min after oxygen inhalation and peaked at 30-40 min, and the increased slope of the DR group was higher than that of the NDR group. The oxygen tension of the preretinal vitreous gradually increased after oxygen inhalation, and the difference between the DR and NDR groups and the control group was statistically significant (P < 0.05). The preretinal vitreous oxygen tension was higher in the optic disc, temporal side, and nasal side in the NDR group than in the control group, and the difference was statistically significant (P < 0.05). The maximum slope ratios of the optic disc and the temporal side of the DR group were greater than those of the control group, and the difference was statistically significant (P < 0.05).
Three-dimensional-SPGR echo MRI sequencing technology is useful for detecting preretinal oxygen tension levels in patients with diabetes. It can be used as one of the functional and imaging observation indicators for the early diagnosis of DR.
本研究旨在利用三维扰相梯度回波（3D-SPGR）序列成像评估无高血压的糖尿病患者的视网膜前氧张力水平，并探讨糖尿病视网膜病变（DR）与视网膜前氧张力变化的相关性。
本研究纳入 15 例无高血压的 2 型糖尿病患者，根据眼底照相检查结果分为糖尿病视网膜病变（DR）组（n=10 眼）和糖尿病无视网膜病变（NDR）组（n=20 眼）。另纳入健康对照组（n=14 眼）。采用 3D-SPGR 回波磁共振成像（MRI）评估吸氧前后眼视网膜前玻璃体内视盘区、鼻侧和颞侧信号强度。信号采集时间为吸氧后 10、20、30、40 和 50min。
结果显示，DR 组和 NDR 组患者在吸氧 10min 后视网膜前玻璃体内氧张力迅速升高，并在 30-40min 时达到峰值，DR 组的升高斜率高于 NDR 组。吸氧后视网膜前玻璃体内氧张力逐渐升高，DR 组和 NDR 组与对照组之间差异均有统计学意义（P<0.05）。NDR 组视盘、颞侧和鼻侧视网膜前玻璃体内氧张力均高于对照组，差异均有统计学意义（P<0.05）。DR 组视盘和颞侧最大斜率比值大于对照组，差异均有统计学意义（P<0.05）。
三维 SPGR 回波 MRI 序列技术有助于检测糖尿病患者的视网膜前氧张力水平，可作为 DR 早期诊断的功能和影像学观察指标之一。
