Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, 00826, Republic of Korea.
BMC Vet Res. 2022 Jul 5;18(1):261. doi: 10.1186/s12917-022-03344-y.
Endothelial cell-specific molecule-1 (ESM-1) has emerged as a potential biomarker for cardiovascular disease in humans. Myxomatous mitral valve disease (MMVD) is the most common heart disease in dogs, and we hypothesized that MMVD causes chronic inflammation that increases susceptibility to endothelial glycocalyx (eGCX) damage. In this study, we measured the concentration of ESM-1 in a group of dogs with MMVD and evaluated factors affecting eGCX damage.
Sixty-four dogs (control, n = 6; MMVD, n = 58) were enrolled in this study. There was no significant difference in serum ESM-1 concentrations among the MMVD stages. The serum ESM-1 concentration was significantly higher in the death group than in the alive group in MMVD dogs. (p = 0.006). In five dogs with MMVD, serum ESM-1 concentrations tended to decrease when the cardiac drug (pimobendan, furosemide, and digoxin) dose was increased.
In cases where MMVD progressed to decompensated heart failure with clinical symptoms and resulted in death, the concentration of serum ESM-1 increased significantly. Therefore, ESM-1 could be utilized as a new potential negative prognostic factor in patients with MMVD.
内皮细胞特异性分子-1（ESM-1）已成为人类心血管疾病的潜在生物标志物。黏液样二尖瓣病变（MMVD）是犬最常见的心脏病，我们假设 MMVD 引起慢性炎症，增加内皮糖萼（eGCX）损伤的易感性。在这项研究中，我们测量了一组 MMVD 犬的 ESM-1 浓度，并评估了影响 eGCX 损伤的因素。
本研究纳入了 64 只狗（对照组，n=6；MMVD 组，n=58）。MMVD 各期血清 ESM-1 浓度无显著差异。MMVD 犬死亡组血清 ESM-1 浓度明显高于存活组（p=0.006）。在 5 只 MMVD 犬中，当心脏药物（匹莫苯丹、呋塞米和地高辛）剂量增加时，血清 ESM-1 浓度有降低的趋势。
在 MMVD 进展为有临床症状的失代偿性心力衰竭并导致死亡的情况下，血清 ESM-1 浓度显著升高。因此，ESM-1 可作为 MMVD 患者新的潜在负性预后因素。
