MCM3AP-AS1在肿瘤发生和肿瘤进展中的作用综述。
A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression.
作者信息
Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Samadian Mohammad
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Cancer Cell Int. 2022 Jul 5;22(1):225. doi: 10.1186/s12935-022-02644-5.
Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 (MCM3AP-AS1) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR-193a-5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR-340-5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis.
微小染色体维持复合体组分3相关蛋白反义1（MCM3AP-AS1）是一个位于21q22.3的RNA基因。该基因座的正义转录本在实体瘤和血液系统恶性肿瘤的发病机制中具有双重作用。MCM3AP-AS1已被证明可结合miR-194-5p、miR-876-5p、miR-543-3p、miR-28-5p、miR-93、miR-545、miR-599、miR-193a-5p、miR-363-5p、miR-204-5p、miR-211-5p、miR-15a、miR-708-5p、miR-138、miR-138-5p、miR-34a、miR-211、miR-340-5p、miR-148a、miR-195-5p和miR-126。一些与癌症相关的信号通路，即PTEN/AKT、PI3K/AKT和ERK1/2，受这种长链非编码RNA影响。细胞系研究、动物研究和临床研究一致报道了MCM3AP-AS1在除宫颈癌外的不同组织中的致癌作用，在宫颈癌中这种长链非编码RNA具有肿瘤抑制作用。在本手稿中，我们从这三种证据来源收集证据，以综述MCM3AP-AS1在致癌过程中的影响。
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