Department of Biotechnology, Central University of Kashmir, Ganderbal, Jammu and Kashmir, India.
Growth Factor Signaling Laboratory, Department of Biotechnology, University of Kashmir, Srinagar, Jammu and Kashmir, India.
J Cell Physiol. 2022 Aug;237(8):3257-3277. doi: 10.1002/jcp.30819. Epub 2022 Jul 5.
Autophagy is an evolutionarily conserved multistep degradation mechanism in eukaryotes, that maintains cellular homoeostasis by replenishing cells with nutrients through catabolic lysis of the cytoplasmic components. This critically coordinated pathway involves sequential processing events that begin with initiation, nucleation, and elongation of phagophores, followed by the formation of double-membrane vesicles known as autophagosomes. Finally, autophagosomes migrate towards and fuse with lysosomes in mammals and vacuoles in yeast and plants, for the eventual degradation of the intravesicular cargo. Here, we review the recent advances in our understanding of the molecular events that define the process of autophagy.
自噬是真核生物中一种进化上保守的多步骤降解机制，通过对细胞质成分进行分解代谢裂解，为细胞提供营养物质，从而维持细胞内的稳态。这个关键协调的途径涉及一系列连续的加工事件，从吞噬体的起始、成核和延伸开始，然后形成双层膜囊泡，称为自噬体。最后，自噬体在哺乳动物中向溶酶体迁移并融合，在酵母和植物中向液泡迁移并融合，最终降解囊泡内的货物。在这里，我们综述了近年来对自噬过程中定义分子事件的理解的进展。
