Synthesis, spectral characterization and antiproliferative activity of new organotin (IV) dithiocarbamate compounds on K562 cells.

Four new organotin(IV) dithiocarbamate compounds with general formulae of PhnSn [SCN(CHCHOCHCH)] for compound 1 and 2; and PhSn[SCN(CH)(CHCHCH)] for compound 3 and 4 were successfully synthesized via in situ insertion method. These compounds namely, diphenyltin(IV)- [1] and triphenyltin(IV) N,N-bis(2-ethoxyethyl)dithiocarbamate [2], diphenyltin(IV)- [3] and triphenyltin(IV) N-methyl-N-phenethyldithiocarbamate [4] were each characterized with CHNS elemental analysis, FT-IR and NMR spectroscopies (H, C and Sn). The compounds were then assessed for their cytotoxicity against K562 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazholium bromide (MTT) assay upon 24 h treatment. All compounds produced the essential IR absorption bands and displayed important NCS peak in C NMR spectroscopy. From the cytotoxicity studies using MTT assay, the compounds were shown to inhibit cell proliferation in K562 leukemic cells with IC values ranging from 1.48 to 4.52 μM, and in the manners more cytotoxic compared to standard used imatinib.