Department of Pulmonary Medicine, ESI Post Graduate Institute of Medical Sciences & Research (ESI-PGIMSR), Basaidarapur, New Delhi.
Monaldi Arch Chest Dis. 2022 Jul 4;93(1). doi: 10.4081/monaldi.2022.2167.
Restless legs syndrome (RLS), a sensory motor disorder, is commonly seen amongst chronic obstructive pulmonary disease (COPD) patients. We conducted a study to know its prevalence in COPD and analyse the possible cause and effect of RLS. It is an analytical cross-sectional study conducted between July 2016-December 2020.The prevalence of RLS was evaluated in patients of COPD using RLS diagnostic criteria. Spirometry, iron profile and arterial blood gas analysis was performed in all the patients to evaluate the cause of RLS. The effect was evaluated with diagnostic criteria for insomnia and patient health questionnaire (PHQ2) for depression. There were 205 participants with a mean age of 59±8 years, 182 (88.7%) men and 23 (11.2%) women. The mean body mass index (BMI) was 29±3.9 kg/m2. The prevalence of RLS was 31.2%. RLS was more common amongst women compared to men (60.8% vs 27.4%). RLS was more prevalent among hypoxemic (PaO2<60 mm Hg) and hypercapnic (PaCO2>45 mm Hg) patients (p<0.016; p<0.017). The ROC curve plotted between PaO2 and RLS occurrence showed that the patients having PaO2 less than 76 mm of Hg were more prone to develop RLS. RLS patients had a higher incidence of insomnia as compared to those without RLS (68.8% vs 36.8%, p<0.001). COPD with RLS patients had more depressive symptoms with a higher patient health questionnaire 2 (PHQ2) score (35.9% vs 14.2%, p<0.001) compared to non-RLS COPD patients. The multiple regression analysis also confirmed that RLS led to insomnia and depressive symptoms in COPD patients. To conclude, RLS is common in COPD patients. RLS leads to insomnia and depression, thus should be identified and treated.
不宁腿综合征（RLS）是一种感觉运动障碍，在慢性阻塞性肺疾病（COPD）患者中较为常见。我们进行了一项研究，旨在了解其在 COPD 中的患病率，并分析 RLS 的可能原因和影响。这是一项在 2016 年 7 月至 2020 年 12 月期间进行的分析性横断面研究。使用 RLS 诊断标准评估 COPD 患者的 RLS 患病率。对所有患者进行肺功能检查、铁谱和动脉血气分析，以评估 RLS 的病因。采用失眠诊断标准和患者健康问卷（PHQ2）评估抑郁对 RLS 的影响。共有 205 名参与者，平均年龄为 59±8 岁，182 名（88.7%）为男性，23 名（11.2%）为女性。平均体重指数（BMI）为 29±3.9kg/m2。RLS 的患病率为 31.2%。与男性相比，女性 RLS 更为常见（60.8% vs 27.4%）。低氧血症（PaO2<60mmHg）和高碳酸血症（PaCO2>45mmHg）患者的 RLS 更为常见（p<0.016；p<0.017）。绘制 PaO2 与 RLS 发生之间的 ROC 曲线显示，PaO2 小于 76mmHg 的患者更容易发生 RLS。与无 RLS 的 COPD 患者相比，RLS 患者失眠的发生率更高（68.8% vs 36.8%，p<0.001）。与非 RLS COPD 患者相比，RLS COPD 患者的抑郁症状更严重，患者健康问卷 2（PHQ2）评分更高（35.9% vs 14.2%，p<0.001）。多因素回归分析也证实 RLS 导致 COPD 患者失眠和抑郁症状。总之，RLS 在 COPD 患者中较为常见。RLS 会导致失眠和抑郁，因此应予以识别和治疗。
