Molecular Nutrition Branch, National Engineering Research Center of Rice and By-Product Deep Processing/College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Crit Rev Food Sci Nutr. 2023 Nov;63(33):11625-11639. doi: 10.1080/10408398.2022.2094889. Epub 2022 Jul 6.
The intestinal microecology is a research hotspot, and neologisms related to the gut such as gut-brain axis, gut-lung axis, gut-bone axis, gut-skin axis, gut-renal axis, and gut-liver axis have emerged from recent research. Meticulous investigation has discovered that food-derived active peptides (FDAPs) are bioactive substances that optimize the structure of the gut microbiota to improve human health. However, few reviews have summarized and emphasized the nutritional value of FDAPs and their mechanisms of action in regulating the composition of the gut microbiota. We aim to provide an update on the latest research on FDAPs by comparing, summarizing, and discussing the potential food sources of FDAPs, their physiological functions, and regulatory effects on the intestinal microecology. The key findings are that few studies have analyzed the potential mechanisms and molecular pathways through which FDAPs maintain intestinal microecological homeostasis. We found that an imbalance in the ratio of and in the gut microbiota and abnormal production of short-chain fatty acids are key to the occurrence and development of various diseases. This review provides theoretical support for future comprehensive research on the digestion, distribution, metabolism, and excretion of FDAPs and the mechanisms underlying the interactions between FDAPs and the intestinal microecology.
肠道微生态是研究热点，近年来，与肠道相关的新词如肠-脑轴、肠-肺轴、肠-骨轴、肠-皮轴、肠-肾轴和肠-肝轴不断涌现。细致的研究发现，食物来源的活性肽（FDAPs）是优化肠道微生物群结构、改善人类健康的生物活性物质。然而，很少有综述总结和强调 FDAPs 的营养价值及其调节肠道微生物群组成的作用机制。我们旨在通过比较、总结和讨论 FDAPs 的潜在食物来源、生理功能及其对肠道微生态的调节作用，为 FDAPs 的最新研究提供更新。主要发现是，很少有研究分析 FDAPs 维持肠道微生态平衡的潜在机制和分子途径。我们发现，肠道微生物群中 和 的比例失衡以及短链脂肪酸的异常产生是各种疾病发生和发展的关键。本综述为未来全面研究 FDAPs 的消化、分布、代谢和排泄以及 FDAPs 与肠道微生态相互作用的机制提供了理论支持。
