He Meng-Jiao, Shen Rong, Wang Hai-Yan, Gui Fei, Song Dan-Dan, Yang Lei
School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Jun;44(3):510-515. doi: 10.3881/j.issn.1000-503X.14245.
Hearing loss is one of the most common chronic developmental diseases.The available studies have demonstrated that the occurrence and development of hearing loss is closely related to oxidative damage caused by oxidative stress.Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase,NOX) contribute to the production of reactive oxygen and are classified into seven subtypes (NOX1,NOX2,NOX3,NOX4,NOX5,DUOX1,and DUOX2).To explore the relationship between oxidative stress and hearing loss,this paper reviews the latest research progress in the pathological mechanism of NOX-mediated oxidative stress and hearing loss.
听力损失是最常见的慢性发育性疾病之一。现有研究表明，听力损失的发生和发展与氧化应激引起的氧化损伤密切相关。烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶，NOX）有助于活性氧的产生，并分为七个亚型（NOX1、NOX2、NOX3、NOX4、NOX5、双氧化酶1和双氧化酶2）。为了探讨氧化应激与听力损失之间的关系，本文综述了NOX介导的氧化应激与听力损失病理机制的最新研究进展。
