Rokutan Kazuhito, Kawahara Tsukasa, Kuwano Yuki, Tominaga Kumiko, Nishida Keisei, Teshima-Kondo Shigetada
Department of Stress Science, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan.
Semin Immunopathol. 2008 Jul;30(3):315-27. doi: 10.1007/s00281-008-0124-5. Epub 2008 Jun 3.
Chronic inflammation caused by Helicobacter pylori infection or inflammatory bowel disease (IBD) is closely linked to cancer development. Innate immune abnormalities and enhanced production of reactive oxygen species through a phagocyte NADPH oxidase (Nox2) are key issues in understanding the pathogenesis of inflammation-dependent carcinogenesis. Besides Nox2, functionally distinct homologues (Nox1, Nox3, Nox4, Nox5, Duox1, and Duox2) have been identified. Nox1 and Duox2 are highly expressed in the gastrointestinal tract. Although the functional roles of Nox/Duox in the gastrointestinal tract are still unclear, we will review their potential roles in the gastrointestinal immunopathology, particularly in H. pylori-induced inflammation, IBD, and malignancy.
幽门螺杆菌感染或炎症性肠病（IBD）引起的慢性炎症与癌症发展密切相关。先天性免疫异常以及通过吞噬细胞NADPH氧化酶（Nox2）增强的活性氧生成是理解炎症依赖性致癌作用发病机制的关键问题。除了Nox2，还鉴定出了功能不同的同源物（Nox1、Nox3、Nox4、Nox5、双氧化酶1和双氧化酶2）。Nox1和双氧化酶2在胃肠道中高度表达。尽管Nox/双氧化酶在胃肠道中的功能作用仍不清楚，但我们将综述它们在胃肠道免疫病理学中的潜在作用，特别是在幽门螺杆菌诱导的炎症、IBD和恶性肿瘤中的作用。
