Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Department of Pharmacy, The Women University, Multan, Pakistan.
Curr Pharm Des. 2022;28(20):1632-1642. doi: 10.2174/1381612828666220705113514.
Resveratrol (RSV) is a natural polyphenolic compound known for its therapeutic activities but has limited bioavailability. The aim of our study was to explore various drug-delivering methods that are being employed to achieve target-oriented delivery and therapeutic performance of RSV. To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made to produce efficient formulations accompanying efficient drug delivery strategies. Several clinical trial studies have been conducted on RSV isomers, and the majority of studies indicated that trans-RSV had better clinical potential and therapeutic effectiveness in various types of complications such as colorectal cancer, metabolic syndrome, hypertension, obesity, neurodegenerative diseases, diabetes, hepatic disease, cardiac disorders, and breast cancer. However, multiple research studies enable us to understand various strategies that can enhance the systemic availability and efficacy of topical RSV formulations. In this article, we emphasize the hurdles of RSV delivery processes. We summarized that the micro- particulate system works efficiently for delivering liquid and solid microparticles of RSV. Another technique in which a coating encloses particles is called microencapsulation. This technique reduces the degradation of pharmaceutical compounds. Similarly, the cyclodextrin system is mainly used for poorly soluble drugs. On the other hand, the vesicular system is another micro-particulate system that can encapsulate hydrophilic and hydrophobic drugs. However, the RSV nanosponge formulations have advanced nano drug delivery systems, making it possible to use RSV for its antioxidant potential.
白藜芦醇（RSV）是一种天然多酚化合物，以其治疗活性而闻名，但生物利用度有限。我们的研究旨在探索各种药物输送方法，以实现 RSV 的靶向输送和治疗效果。为了提高 RSV 的生物利用度和药代动力学特性，正在努力开发伴随高效药物传递策略的有效制剂。已经对 RSV 异构体进行了几项临床试验研究，大多数研究表明，反式-RSV 在结直肠癌、代谢综合征、高血压、肥胖症、神经退行性疾病、糖尿病、肝病、心脏病和乳腺癌等各种类型的并发症中具有更好的临床潜力和治疗效果。然而，多项研究使我们能够了解可以提高局部 RSV 制剂的全身可用性和功效的各种策略。在本文中，我们强调了 RSV 传递过程中的障碍。我们总结了微粒系统可有效地用于输送 RSV 的液体和固体微粒。另一种技术是将颗粒包裹在涂层中，称为微囊化。该技术可减少药物化合物的降解。同样，环糊精系统主要用于难溶性药物。另一方面，囊泡系统是另一种微粒系统，可封装亲水性和疏水性药物。然而，RSV 纳米海绵制剂具有先进的纳米药物传递系统，使得 RSV 有可能用于其抗氧化潜力。
