Yan Dawei, Li Xuesong, Wang Zhanxin, Liu Xingpo, Dong Xuan, Fu Rui, Su Xin, Xu Bangfeng, Teng Qiaoyang, Yuan Chunxiu, Zhang Zhifei, Liu Qinfang, Li Zejun
Department of Avian Infectious Disease, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, PR China.
Key Laboratory of Healthy Animal Husbandry and Environmental Control of Guangdong Province, Wen's Foodstuffs Group Co., Ltd., Xinxing 527400, Guangdong, PR China.
Vet Microbiol. 2022 Sep;272:109500. doi: 10.1016/j.vetmic.2022.109500. Epub 2022 Jun 30.
In 2021, a chicken Tembusu virus (TMUV) caused outbreaks of a disease characterized by retarded growth and egg production decline in chickens in China. Two TMUV strains SD2021 and GX2021 were isolated from the diseased chickens and phylogenetic analysis of the E gene nucleotide sequence revealed that the chicken TMUV SD2021 and GX2021 were most close to mosquito origin TMUV in Cluster 3.2, which was distinct from the prevalent duck TMUVs in Cluster 2. The TMUV SD2021 caused growth retardation and neurological symptoms in chickens through both intranasal and intramuscular infection routes, but has no direct-contact transmissibility among chickens. The findings of this study highlight the pathogenicity of a chicken adapted mosquito-origin TMUV in chickens in China.
2021年，一种鸡坦布苏病毒（TMUV）在中国引发了鸡群疾病暴发，其特征为生长迟缓及产蛋量下降。从患病鸡中分离出两株TMUV毒株SD2021和GX2021，对E基因核苷酸序列的系统发育分析显示，鸡TMUV SD2021和GX2021与3.2簇中源自蚊子的TMUV最为接近，这与2簇中流行的鸭TMUV不同。TMUV SD2021通过鼻内和肌肉注射感染途径均可导致鸡生长迟缓及出现神经症状，但在鸡之间无直接接触传播性。本研究结果凸显了一种适应鸡的源自蚊子的TMUV在中国鸡群中的致病性。
