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在仿生膜中，具有或不具有银纳米粒子的甘氨酸-组氨酸基二肽的自组装体的抗氧化、细胞毒性和抗菌性能。

Antioxidative, cytotoxic, and antibacterial properties of self-assembled glycine-histidine-based dipeptides with or without silver nanoparticles in bio-inspired film.

机构信息

University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Ankara, Turkey.

University of Health Sciences Turkey, Gülhane Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.

出版信息

Arh Hig Rada Toksikol. 2022 Jul 7;73(2):169-177. doi: 10.2478/aiht-2022-73-3658.

DOI:10.2478/aiht-2022-73-3658
PMID:35792768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9287833/
Abstract

Recent years have seen much attention being given to self-assembly of dipeptide-based structures, especially to self-regulation of dipeptide structures with different amino acid sequences. In this study we investigated the effects of varying solvent environments on the self-assembly of glycine-histidine (Gly-His) dipeptide structures. First we determined the morphological properties of Gly-His films formed in different solvent environments with scanning electron microscopy and then structural properties with Fourier-transform infrared (FTIR) spectroscopy. In addition, we studied the effects of Gly-His films on silver nanoparticle (AgNP) formation and the antioxidant and cytotoxic properties of AgNPs obtained in this way. We also, assessed antibacterial activities of Gly-His films against Gram-negative and and Gram-positive . Silver nanoparticle-decorated Gly-His films were not significantly cytotoxic at concentrations below 2 mg/mL but had antibacterial activity. We therefore believe that AgNP-decorated Gly-His films at concentrations below 2 mg/mL can be used safely against bacteria.

摘要

近年来，人们对二肽基结构的自组装给予了极大的关注，特别是对不同氨基酸序列的二肽结构的自我调节给予了极大的关注。在这项研究中，我们研究了不同溶剂环境对甘氨酰-组氨酸（Gly-His）二肽结构自组装的影响。首先，我们用扫描电子显微镜确定了在不同溶剂环境中形成的 Gly-His 薄膜的形态特性，然后用傅里叶变换红外（FTIR）光谱确定了结构特性。此外，我们研究了 Gly-His 薄膜对银纳米颗粒（AgNP）形成的影响，以及以这种方式获得的 AgNP 的抗氧化和细胞毒性特性。我们还评估了 Gly-His 薄膜对革兰氏阴性和革兰氏阳性的抗菌活性。银纳米粒子修饰的 Gly-His 薄膜在低于 2mg/ml 的浓度下没有明显的细胞毒性，但具有抗菌活性。因此，我们认为浓度低于 2mg/ml 的 AgNP 修饰的 Gly-His 薄膜可以安全地用于对抗细菌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/059ead699faa/aiht-73-169-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/b5be642f80b1/aiht-73-169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/3def88872e83/aiht-73-169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/fa3d4055d355/aiht-73-169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/7e4ab8291ad7/aiht-73-169-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/74d0d6f04560/aiht-73-169-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/44c50e1a850d/aiht-73-169-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/a2472c89ca24/aiht-73-169-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/59c7b422fc7f/aiht-73-169-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/059ead699faa/aiht-73-169-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/b5be642f80b1/aiht-73-169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/3def88872e83/aiht-73-169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/fa3d4055d355/aiht-73-169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/7e4ab8291ad7/aiht-73-169-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/74d0d6f04560/aiht-73-169-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/44c50e1a850d/aiht-73-169-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/a2472c89ca24/aiht-73-169-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/59c7b422fc7f/aiht-73-169-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdba/9287833/059ead699faa/aiht-73-169-g009.jpg

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